asp-4 Aspartic protease 4 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: asp-4
Official Full Name: Aspartic protease 4
Primary source: WormBase:WBGene00000217
Locus tag: CELE_R12H7.2
See related: AllianceGenome:WB:WBGene00000217
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aspartic-type endopeptidase activity. Involved in necrotic cell death and proteolysis. Located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension (multiple); neuronal ceroid lipofuscinosis 10; and portal hypertension. Orthologous to several human genes including CTSD (cathepsin D). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables aspartic-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in programmed cell death	IEA Inferred from Electronic Annotation more info
involved_in programmed necrotic cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info

NP_510191.1

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