ncr-1 NPC intracellular cholesterol transporter 1 homolog 1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: ncr-1
Official Full Name: NPC intracellular cholesterol transporter 1 homolog 1
Primary source: WormBase:WBGene00003561
Locus tag: CELE_F02E8.6
See related: AllianceGenome:WB:WBGene00003561
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including cholesterol homeostasis; positive regulation of growth rate; and regulation of oviposition. Predicted to be located in late endosome and lysosome. Is expressed in several structures, including head neurons; hermaphrodite gonad; hypodermis; lumbar neurons; and pharynx. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to several human genes including NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intestinal cholesterol absorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_508771.1

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The following sections contain reference sequences that belong to a specific genome build. Explain