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    lst-2 Lateral signaling target protein 2 [ Caenorhabditis elegans ]

    Gene ID: 180712, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lst-2
    Official Full Name
    Lateral signaling target protein 2
    Primary source
    WormBase:WBGene00003084
    Locus tag
    CELE_R160.7
    See related
    AllianceGenome:WB:WBGene00003084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See lst-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (4378004..4383366, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF4492 domain-containing protein Neighboring gene Methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP-2 complex subunit mu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Mosesson Y, et al. Dev Cell, 2009 May. PMID 19460345, Free PMC Article
    2. Executing multicellular differentiation: quantitative predictive modelling of C.elegans vulval development. Bonzanni N, et al. Bioinformatics, 2009 Aug 15. PMID 19515963
    3. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
    4. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Yoo AS, et al. Science, 2004 Jan 30. PMID 14752159
    5. RTK/Ras/MAPK signaling. Sundaram MV. WormBook, 2006 Feb 11. PMID 18050474, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Lateral signaling target protein 2
    NP_508756.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4378004..4383366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076355.6 → NP_508756.2  Lateral signaling target protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508756.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TZD0
      Conserved Domains (2) summary
      cd15731
      Location:559 → 623
      FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
      pfam05285
      Location:361 → 453
      SDA1; SDA1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TZD0.2

    Gene LinkOut

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