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    swan-1 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179876, updated on 18-Sep-2024

    Summary

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    Official Symbol
    swan-1
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00009977
    Locus tag
    CELE_F53C11.8
    See related
    AllianceGenome:WB:WBGene00009977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables LIM domain binding activity and small GTPase binding activity. Involved in several processes, including negative regulation of phagocytosis, engulfment; regulation of GTPase activity; and regulation of axon extension. Located in cytoplasm. Is expressed widely. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See swan-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (13804395..13807237, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1. Shao Z, et al. PLoS Pathog, 2010 Aug 26. PMID 20865124, Free PMC Article
    2. SWAN-1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function. Yang Y, et al. Genetics, 2006 Dec. PMID 16980389, Free PMC Article
    3. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. Ritterhoff S, et al. EMBO J, 2010 Nov 17. PMID 20940704, Free PMC Article
    4. CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Ma DK, et al. Neuron, 2012 Mar 8. PMID 22405203, Free PMC Article
    5. A model to die for: signaling to apoptotic cell removal in worm, fly and mouse. Kinchen JM. Apoptosis, 2010 Sep. PMID 20461556

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data support a model in which SWAN-1, MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 fast killing.
      Title: C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables LIM domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of phagocytosis, engulfment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_506418.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13804395..13807237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074017.8 → NP_506418.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93758
      Conserved Domains (2) summary
      COG2319
      Location:36 → 369
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:68 → 110
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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