glr-5 GLutamate Receptor family (AMPA) [Caenorhabditis elegans] - Gene

Summary

Official Symbol: glr-5
Official Full Name: GLutamate Receptor family (AMPA)
Primary source: WormBase:WBGene00001616
Locus tag: CELE_ZC196.7
See related: AllianceGenome:WB:WBGene00001616
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutamate receptor activity and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be integral component of membrane. Predicted to be active in postsynaptic membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive non-syndromic intellectual disability; and childhood absence epilepsy. Orthologous to several human genes including GRIK1 (glutamate ionotropic receptor kainate type subunit 1) and GRIK3 (glutamate ionotropic receptor kainate type subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

NP_505244.1

Product from WormBase gene class glr;
Partially confirmed by transcript evidence

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The following sections contain reference sequences that belong to a specific genome build. Explain