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    tat-6 Phospholipid-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 178754, updated on 18-Sep-2024

    Summary

    Official Symbol
    tat-6
    Official Full Name
    Phospholipid-transporting ATPase
    Primary source
    WormBase:WBGene00017174
    Locus tag
    CELE_F02C9.3
    See related
    AllianceGenome:WB:WBGene00017174
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human ATP9B (ATPase phospholipid transporting 9B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See tat-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (3129103..3133412)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Receptor L-domain domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Phospholipid-transporting ATPase
    NP_503858.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      3129103..3133412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071457.2NP_503858.1  Phospholipid-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503858.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91203
      Conserved Domains (6) summary
      TIGR01652
      Location:931063
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:151388
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:492590
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:86144
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8291057
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:782824
      HAD_like; Haloacid Dehalogenase-like Hydrolases