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    elo-2 Long chain fatty acid elongase 2 [ Caenorhabditis elegans ]

    Gene ID: 178532, updated on 17-Oct-2024

    Summary

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    Official Symbol
    elo-2
    Official Full Name
    Long chain fatty acid elongase 2
    Primary source
    WormBase:WBGene00001240
    Locus tag
    CELE_F11E6.5
    See related
    AllianceGenome:WB:WBGene00001240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acid elongase activity. Involved in several processes, including determination of adult lifespan; lipid metabolic process; and regulation of gene expression. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in intestine; pharyngeal muscle cell; tail; uterus; and ventral nerve cord. Orthologous to human ELOVL3 (ELOVL fatty acid elongase 3) and ELOVL6 (ELOVL fatty acid elongase 6). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See elo-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (17466062..17467408, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Transmembrane protein Neighboring gene TIGR04139 family peptide modification target;TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene Ascaris suum EPICuticlin protein related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. miR-786 regulation of a fatty-acid elongase contributes to rhythmic calcium-wave initiation in C. elegans. Kemp BJ, et al. Curr Biol, 2012 Dec 4. PMID 23141108, Free PMC Article
    2. Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis. Ling Y, et al. Chin J Nat Med, 2019 Dec. PMID 31882042
    3. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Kniazeva M, et al. Genetics, 2003 Jan. PMID 12586704, Free PMC Article
    4. Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1. Nomura T, et al. Genes Nutr, 2010 Mar. PMID 19936816, Free PMC Article
    5. Polyunsaturated fatty acids are involved in regulatory mechanism of fatty acid homeostasis via daf-2/insulin signaling in Caenorhabditis elegans. Horikawa M, et al. Mol Cell Endocrinol, 2010 Jul 29. PMID 20226839

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ELO-2 cooperates with the previously reported ELO-1 in 20-carbon PUFA production.
      Title: Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Long chain fatty acid elongase 2
    NP_503114.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17466062..17467408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070713.9 → NP_503114.1  Long chain fatty acid elongase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503114.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XVQ9
      Conserved Domains (1) summary
      pfam01151
      Location:29 → 269
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVQ9.1

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