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    flp-1 SQPNFLRF-amide [ Caenorhabditis elegans ]

    Gene ID: 177737, updated on 18-Sep-2024

    Summary

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    Official Symbol
    flp-1
    Official Full Name
    SQPNFLRF-amide
    Primary source
    WormBase:WBGene00001444
    Locus tag
    CELE_F23B2.5
    See related
    AllianceGenome:WB:WBGene00001444
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables neuropeptide receptor binding activity. Involved in several processes, including mechanosensory behavior; neuropeptide signaling pathway; and regulation of oviposition. Predicted to be located in extracellular region. Is expressed in nerve ring and neurons. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See flp-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (9144705..9146128)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Intraflagellar transport protein 122 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerases I, II, and III subunit RPABC4 Neighboring gene Chromatin target of PRMT1 protein C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response. Jia Q, et al. Nat Commun, 2021 Apr 16. PMID 33863916, Free PMC Article
    2. Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network. Oranth A, et al. Neuron, 2018 Dec 19. PMID 30392795
    3. Identification of a platyhelminth neuropeptide receptor. Omar HH, et al. Int J Parasitol, 2007 Jun. PMID 17362965
    4. Structure-activity relationships of an inhibitory nematode FMRFamide-related peptide, SDPNFLRFamide (PF1), on Ascaris suum muscle. Bowman JW, et al. Int J Parasitol, 2002 Dec 19. PMID 12464423
    5. APEASPFIRFamide, a novel FMRFamide-related decapeptide from Caenorhabditis elegans: structure and myoactivity. Marks NJ, et al. Biochem Biophys Res Commun, 1997 Feb 24. PMID 9070852

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.
      Title: Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.
    2. Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.
      Title: Mitochondrial hydrogen peroxide positively regulates neuropeptide secretion during diet-induced activation of the oxidative stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables neuropeptide receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to serotonin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SQPNFLRF-amide
    NP_501592.1
    • Confirmed by transcript evidence
    NP_872077.1
    • Confirmed by transcript evidence
    NP_872078.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9144705..9146128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069191.8 → NP_501592.1  SQPNFLRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41855, Q7JKL0, Q8I122

    2. NM_182277.9 → NP_872077.1  SQPNFLRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872077.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41855

    3. NM_182278.7 → NP_872078.1  SQPNFLRF-amide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872078.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P41855
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41855.1

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