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    sqv-1 UDP-glucuronate decarboxylase [ Caenorhabditis elegans ]

    Gene ID: 177631, updated on 17-Oct-2024

    Summary

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    Official Symbol
    sqv-1
    Official Full Name
    UDP-glucuronate decarboxylase
    Primary source
    WormBase:WBGene00005019
    Locus tag
    CELE_D2096.4
    See related
    AllianceGenome:WB:WBGene00005019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable NAD+ binding activity and UDP-glucuronate decarboxylase activity. Involved in several processes, including oviposition; pharynx development; and vulval development. Located in cytoplasm. Is expressed in coelomocyte; oocyte; uterus; and vulva. Orthologous to human UXS1 (UDP-glucuronate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See sqv-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (8361117..8363426)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene TransThyretin-Related family domain Neighboring gene TransThyretin-Related family domain Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytokinesis: GAGs form the walls that separate our parts. White J, et al. Curr Biol, 2003 Sep 16. PMID 13678612
    2. The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. Hwang HY, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391314, Free PMC Article
    3. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid alpha-glucosidase in Caenorhabditis elegans. Sikora J, et al. Mol Cell Biochem, 2010 Aug. PMID 20349118
    4. The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated. Hwang HY, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12391315, Free PMC Article
    5. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927677, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-D-xylose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucuronate decarboxylase
    NP_001368459.1
    • Confirmed by transcript evidence
    NP_501418.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8361117..8363426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069017.8 → NP_501418.1  UDP-glucuronate decarboxylase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF65
      Conserved Domains (1) summary
      cd05230
      Location:137 → 441
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

    2. NM_001380358.1 → NP_001368459.1  UDP-glucuronate decarboxylase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M5R6
      Conserved Domains (1) summary
      cd05230
      Location:82 → 386
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version

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