lgc-37 Ligand-Gated ion Channel [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lgc-37
Official Full Name: Ligand-Gated ion Channel
Primary source: WormBase:WBGene00013914
Locus tag: CELE_ZC482.5
See related: AllianceGenome:WB:WBGene00013914
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in several processes, including chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection and synapse. Predicted to be integral component of plasma membrane. Is expressed in body wall musculature and neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autistic disorder; epilepsy (multiple); familial febrile seizures 8; and multiple sclerosis. Orthologous to several human genes including GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1); GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2); and GABRA6 (gamma-aminobutyric acid type A receptor subunit alpha6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See lgc-37 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (12785154..12793176)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC482.5 (e-PCR)
- UniSTS:313601

BE10.1 (e-PCR)
- UniSTS:305559

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ligand-Gated ion Channel

NP_499662.2

Confirmed by transcript evidence;
Product from WormBase gene class lgc

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

12785154..12793176

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067261.7 → NP_499662.2 Ligand-Gated ion Channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499662.2

Status: REVIEWED

UniProtKB/TrEMBL

G5ECN1

Conserved Domains (3) summary

TIGR00860
Location:44 → 464

LIC; Cation transporter family protein

pfam02931
Location:45 → 254

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:262 → 461

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region