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    tba-7 Tubulin alpha chain [ Caenorhabditis elegans ]

    Gene ID: 176568, updated on 17-Oct-2024

    Summary

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    Official Symbol
    tba-7
    Official Full Name
    Tubulin alpha chain
    Primary source
    WormBase:WBGene00006533
    Locus tag
    CELE_T28D6.2
    See related
    AllianceGenome:WB:WBGene00006533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Is expressed in touch receptor neurons. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See tba-7 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (11368351..11371788, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ANK_REP_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene Cystatin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prolyl 4-hydroxylase subunit alpha-1 Neighboring gene Glycosyltransferase family 92 protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Correction for Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. . Mol Biol Cell, 2017 Dec 1. PMID 29187573, Free PMC Article
    2. Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. Zheng C, et al. Mol Biol Cell, 2017 Oct 15. PMID 28835377, Free PMC Article
    3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tubulin alpha chain
    NP_499463.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11368351..11371788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067062.7 → NP_499463.1  Tubulin alpha chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18154
      Conserved Domains (2) summary
      PTZ00335
      Location:1 → 443
      PTZ00335; tubulin alpha chain; Provisional
      cd02186
      Location:2 → 430
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein
    Heading Accession and Version

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