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    unc-69 Short coiled-coil protein;Short coiled-coil protein homolog [ Caenorhabditis elegans ]

    Gene ID: 176444, updated on 18-Sep-2024

    Summary

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    Official Symbol
    unc-69
    Official Full Name
    Short coiled-coil protein;Short coiled-coil protein homolog
    Primary source
    WormBase:WBGene00006802
    Locus tag
    CELE_T07A5.6
    See related
    AllianceGenome:WB:WBGene00006802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Is expressed in ganglia; neurons; and somatic nervous system. Orthologous to human SCOC (short coiled-coil protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See unc-69 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (10318939..10320019)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein unc-50 Neighboring gene Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 Neighboring gene Spindle assembly abnormal protein 7 Neighboring gene Annexin Neighboring gene COMM domain-containing protein Neighboring gene JmjC domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coiling up with SCOC and WAC: two new regulators of starvation-induced autophagy. Joachim J, et al. Autophagy, 2012 Sep. PMID 22717455, Free PMC Article
    2. Fasciculation and elongation zeta proteins 1 and 2: From structural flexibility to functional diversity. Teixeira MB, et al. World J Biol Chem, 2019 Feb 21. PMID 30815230, Free PMC Article
    3. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Hengartner MO, et al. Cell, 1994 Feb 25. PMID 7907274
    4. Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans. Kodoyianni V, et al. Mol Biol Cell, 1992 Nov. PMID 1457827, Free PMC Article
    5. Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans. Kinchen JM, et al. Nature, 2005 Mar 3. PMID 15744306

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Short coiled-coil protein;Short coiled-coil protein homolog
    NP_001022752.1
    • Confirmed by transcript evidence
    NP_001022753.1
    • Confirmed by transcript evidence
    NP_001122717.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10318939..10320019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027581.5 → NP_001022752.1  Short coiled-coil protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U377
      Conserved Domains (1) summary
      pfam10224
      Location:46 → 92
      DUF2205; Predicted coiled-coil protein (DUF2205)

    2. NM_001027582.4 → NP_001022753.1  Short coiled-coil protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDQ5
      Conserved Domains (1) summary
      pfam10224
      Location:46 → 92
      DUF2205; Predicted coiled-coil protein (DUF2205)

    3. NM_001129245.5 → NP_001122717.1  Short coiled-coil protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7LPF8
      Conserved Domains (1) summary
      pfam10224
      Location:46 → 92
      DUF2205; Predicted coiled-coil protein (DUF2205)
    Nucleotide Protein
    Heading Accession and Version

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