tax-4 Cyclic nucleotide-gated channel [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tax-4
Official Full Name: Cyclic nucleotide-gated channel
Primary source: WormBase:WBGene00006526
Locus tag: CELE_ZC84.2
See related: AllianceGenome:WB:WBGene00006526
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables intracellular cAMP-activated cation channel activity and intracellular cGMP-activated cation channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; negative regulation of cGMP-mediated signaling; and positive regulation of macromolecule metabolic process. Located in ciliary inversin compartment; dendrite; and non-motile cilium. Part of cation channel complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in achromatopsia 2; color blindness; retinitis pigmentosa; and retinitis pigmentosa 49. Orthologous to several human genes including CNGA2 (cyclic nucleotide gated channel subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See tax-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (9181546..9185888)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
Title: Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel.
tax-4 cryo-electron microscopy structure provides a new framework for understanding mechanisms of ion permeation, gating and channelopathy of cyclic-nucleotide-gated channels and cyclic nucleotide modulation of related channels
Title: Structure of a eukaryotic cyclic-nucleotide-gated channel.
The results suggest that sensory transduction genes tax-4 and tax-2 are necessary for the proper assembly of presynapses.
Title: Sensory transduction channel subunits, tax-4 and tax-2, modify presynaptic molecular architecture in C. elegans.
By recording from the C. elegans thermosensory neurons AFD in vivo, we found that ion channels TAX-2 and TAX-4 are involved in temperature sensing by a cGMP-mediated pathway
Title: Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans.
Wild-type worms are induced to display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium; this was abolished in chemotaxis-defective tax-4 mutants.
Title: Chemosensory control of surface antigen switching in the nematode Caenorhabditis elegans.
Mutants in tax-4 showed abnormal thermal responses, suggesting that these genes are involved in warm avoidance.
Title: Distribution and movement of Caenorhabditis elegans on a thermal gradient.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC84.2 (e-PCR)
- UniSTS:308234

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP binding	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aerotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of carbon dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal reproductive process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cGMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hyperoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxygen levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cation channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary inversin compartment	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cyclic nucleotide-gated channel

NP_499033.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9181546..9185888

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066632.6 → NP_499033.1 Cyclic nucleotide-gated channel [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499033.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P90800, Q03611

Conserved Domains (3) summary

PLN03192
Location:208 → 564

PLN03192; Voltage-dependent potassium channel; Provisional

cd00038
Location:493 → 610

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam16526
Location:609 → 675

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels