sas-4 Spindle assembly abnormal protein 4 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: sas-4
Official Full Name: Spindle assembly abnormal protein 4
Primary source: WormBase:WBGene00004726
Locus tag: CELE_F10E9.8
See related: AllianceGenome:WB:WBGene00004726
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in centriole replication and maintenance of protein location. Located in centriole. Is expressed in gonad; intestinal cell; and sperm. [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See sas-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (8314349..8318588, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Centriolar SAS-4 remains in dynamic equilibrium with the cytoplasmic pool until late prophase, when it is stably incorporated in a step that requires gamma-tubulin and microtubule assembly.
Title: SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.
SAS-4 is recruited to the centrosome once per cell cycle, at the time of organelle duplication; then to the daughter centriole or a closely associated structure. SAS-4 recruitment is a key step in the centrosome duplication cycle.
Title: SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle.
SAS-4 is a centriole-associated component whose amount dictates centrosome size
Title: SAS-4 is a C. elegans centriolar protein that controls centrosome size.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

STS3-170 (e-PCR)
- UniSTS:242013

F10E9.8 (e-PCR)
- UniSTS:309661

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in centriole replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Spindle assembly abnormal protein 4

NP_498828.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8314349..8318588 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066427.8 → NP_498828.2 Spindle assembly abnormal protein 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498828.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P34402

Conserved Domains (2) summary

pfam10211
Location:394 → 481

Ax_dynein_light; Axonemal dynein light chain

cl19849
Location:439 → 541

DUF881; Bacterial protein of unknown function (DUF881)