ten-1 EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ten-1
Official Full Name: EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein
Primary source: WormBase:WBGene00006498
Locus tag: CELE_R13F6.4
See related: AllianceGenome:WB:WBGene00006498
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including axon development; gonad development; and post-embryonic animal morphogenesis. Located in nucleus and plasma membrane. Is expressed in several structures, including body muscle cell; epithelial cell; gonad; hypodermis; and nervous system. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to several human genes including TENM1 (teneurin transmembrane protein 1); TENM2 (teneurin transmembrane protein 2); and TENM3 (teneurin transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ten-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 20

Sequence:: Chromosome: III; NC_003281.10 (6820935..6847283)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo
Title: Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV-mediated basement membrane integrity during late elongation of the embryo.
Results are consistent with ten-1 normally providing a function complementary to the cytoskeletal remodeling processes that occur in migrating cells or cells undergoing morphogenesis.
Title: C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.
ten-1 is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1
Title: Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.
Ten-1 acts as a receptor for morphogenetic cue(s) and directly signals to the nucleus by translocation of its intracellular domain to the nucleus following its proteolytic release from the cell membrane.
Title: ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13F6.4 (e-PCR)
- UniSTS:311602

STS3-155 (e-PCR)
- UniSTS:241996

F28F5.1 (e-PCR)
- UniSTS:318175

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane assembly involved in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic body morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inductive cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharynx development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sexual reproduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: EGF-like domain-containing protein;Teneurin-1;Tox-GHH domain-containing protein

NP_001022723.2

Confirmed by transcript evidence

NP_001254940.1

Partially confirmed by transcript evidence

NP_001254941.1

Partially confirmed by transcript evidence

NP_001379903.1

Confirmed by transcript evidence

NP_498487.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6820935..6847283

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268011.3 → NP_001254940.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254940.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZUX0

Conserved Domains (5) summary

cd05819
Location:1335 → 1372

NHL; NHL repeat [structural motif]

pfam07974
Location:662 → 686

EGF_2; EGF-like domain

pfam12785
Location:792 → 896

VESA1_N; Variant erythrocyte surface antigen-1

pfam15636
Location:2763 → 2835

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1305 → 1663

NHL; NHL repeat unit of beta-propeller proteins
NM_001268012.3 → NP_001254941.1 EGF-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254941.1

Status: REVIEWED

UniProtKB/TrEMBL

H1ZUX1

Conserved Domains (5) summary

cd05819
Location:1261 → 1298

NHL; NHL repeat [structural motif]

pfam07974
Location:588 → 612

EGF_2; EGF-like domain

pfam12785
Location:718 → 822

VESA1_N; Variant erythrocyte surface antigen-1

pfam15636
Location:2689 → 2761

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1231 → 1589

NHL; NHL repeat unit of beta-propeller proteins
NM_001027552.5 → NP_001022723.2 Teneurin-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022723.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B5BM17, G5EGQ6, Q5CCJ6

Conserved Domains (5) summary

cd05819
Location:1182 → 1219

NHL; NHL repeat [structural motif]

pfam07974
Location:509 → 533

EGF_2; EGF-like domain

pfam12785
Location:639 → 743

VESA1_N; Variant erythrocyte surface antigen-1

pfam15636
Location:2610 → 2682

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

cl18310
Location:1152 → 1510

NHL; NHL repeat unit of beta-propeller proteins
NM_001392130.1 → NP_001379903.1 Teneurin-1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (6) summary

cd05819
Location:1000 → 1037

NHL; NHL repeat [structural motif]

cl18310
Location:970 → 1328

NHL; NHL repeat unit of beta-propeller proteins

pfam00053
Location:262 → 313

Laminin_EGF; Laminin EGF domain

pfam15636
Location:2428 → 2500

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

NF033662
Location:578 → 595

acid_disulf_rpt; acidic double-disulfide repeat

cl19567
Location:306 → 351

DSL; Delta serrate ligand
NM_066086.8 → NP_498487.2 Tox-GHH domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498487.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8I7J1

Conserved Domains (1) summary

pfam15636
Location:815 → 853

Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin