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    cid-1 4Fe-4S ferredoxin-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175707, updated on 17-Oct-2024

    Summary

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    Official Symbol
    cid-1
    Official Full Name
    4Fe-4S ferredoxin-type domain-containing protein
    Primary source
    WormBase:WBGene00019629
    Locus tag
    CELE_K10D2.3
    See related
    AllianceGenome:WB:WBGene00019629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA uridylyltransferase activity. Involved in RNA 3' uridylation. Located in P granule; condensed nuclear chromosome; and perinuclear region of cytoplasm. Is expressed in germ line and intestine. Human ortholog(s) of this gene implicated in liver benign neoplasm. Orthologous to several human genes including TUT7 (terminal uridylyl transferase 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See cid-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    12
    Sequence:
    Chromosome: III; NC_003281.10 (5173922..5180507)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Anaphase-promoting complex subunit emb-1 Neighboring gene ncRNA Neighboring gene PAP-associated domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans. Vieux KF, et al. Nucleic Acids Res, 2021 Nov 8. PMID 34586415, Free PMC Article
    2. CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA. Wang Y, et al. BMC Biol, 2020 Sep 4. PMID 32887607, Free PMC Article
    3. Using Diverse Model Systems to Define Intestinal Epithelial Defenses to Enteric Viral Infections. Segrist E, et al. Cell Host Microbe, 2020 Mar 11. PMID 32164844, Free PMC Article
    4. emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex. Shakes DC, et al. Genetics, 2011 Oct. PMID 21775471, Free PMC Article
    5. CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. van Wolfswinkel JC, et al. Cell, 2009 Oct 2. PMID 19804759

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans.
      Title: Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans.
    2. CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA.
      Title: CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA.
    3. The cde-1 gene, K10D2.3, encodes the TRF-like nucleotidyltransferases CDE-1, study found that CDE-1 is required for the uridylation of CSR-1 bound siRNAs and chromosome segregation.
      Title: CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA 3' uridylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    4Fe-4S ferredoxin-type domain-containing protein
    NP_498099.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5173922..5180507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065698.6 → NP_498099.1  4Fe-4S ferredoxin-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498099.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09409
      Conserved Domains (3) summary
      cd05402
      Location:1029 → 1151
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:1034 → 1317
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam03828
      Location:574 → 625
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein
    Heading Accession and Version

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