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    tbb-2 Tubulin beta-2 chain [ Caenorhabditis elegans ]

    Gene ID: 175519, updated on 17-Oct-2024

    Summary

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    Official Symbol
    tbb-2
    Official Full Name
    Tubulin beta-2 chain
    Primary source
    WormBase:WBGene00006537
    Locus tag
    CELE_C36E8.5
    See related
    AllianceGenome:WB:WBGene00006537
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in meiotic spindle organization. Located in spindle microtubule. Is expressed in several structures, including excretory cell; neurons; oocyte; pharyngeal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations (multiple); congenital fibrosis of the extraocular muscles 3A; congenital symmetric circumferential skin creases 1; hypomyelinating leukodystrophy 6; and torsion dystonia 4. Orthologous to several human genes including TUBB3 (tubulin beta 3 class III); TUBB4A (tubulin beta 4A class IVa); and TUBB6 (tubulin beta 6 class V). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See tbb-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (4015910..4017627, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SH3 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene snRNA-activating protein complex subunit 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth. Chaaban S, et al. Dev Cell, 2018 Oct 22. PMID 30245157
    2. Maternally expressed and partially redundant beta-tubulins in Caenorhabditis elegans are autoregulated. Ellis GC, et al. J Cell Sci, 2004 Jan 26. PMID 14702387
    3. Rapamycin-induced protein dimerization as a tool for C. elegans research​. Mangal S, et al. MicroPubl Biol, 2018 Mar 20. PMID 32550365, Free PMC Article
    4. Paternally contributed centrioles exhibit exceptional persistence in C. elegans embryos. Balestra FR, et al. Cell Res, 2015 May. PMID 25906994, Free PMC Article
    5. Motor neuron synapse and axon defects in a C. elegans alpha-tubulin mutant. Baran R, et al. PLoS One, 2010 Mar 11. PMID 20300184, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic spindle organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of tubulin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tubulin beta-2 chain
    NP_497806.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4015910..4017627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065405.8 → NP_497806.1  Tubulin beta-2 chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52275
      Conserved Domains (2) summary
      PLN00220
      Location:1 → 448
      PLN00220; tubulin beta chain; Provisional
      cd02187
      Location:2 → 426
      beta_tubulin; The beta-tubulin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52275.1

    Gene LinkOut

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