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    imb-2 Importin N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175094, updated on 18-Sep-2024

    Summary

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    Official Symbol
    imb-2
    Official Full Name
    Importin N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00002076
    Locus tag
    CELE_R06A4.4
    See related
    AllianceGenome:WB:WBGene00002076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in cytoplasm. Orthologous to several human genes including TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See imb-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (14365701..14373901)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pre-mRNA 3' end processing protein pfs-2 Neighboring gene SPK domain-containing protein Neighboring gene AcetylCholine Receptor Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Histone-lysine N-methyltransferase mes-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor. Alqadah A, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31767767, Free PMC Article
    2. Redox-dependent control of FOXO/DAF-16 by transportin-1. Putker M, et al. Mol Cell, 2013 Feb 21. PMID 23333309
    3. Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. Senchuk MM, et al. PLoS Genet, 2018 Mar. PMID 29522556, Free PMC Article
    4. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article
    5. Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression. Lamitina T, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16880390, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Importin N-terminal domain-containing protein
    NP_001309574.1
    • Confirmed by transcript evidence
    NP_496987.1
    • Confirmed by transcript evidence
    NP_496988.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14365701..14373901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322761.3 → NP_001309574.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBF9
      Conserved Domains (2) summary
      COG5215
      Location:15 → 764
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:388 → 416
      HEAT; HEAT repeat [structural motif]

    2. NM_064587.5 → NP_496988.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62333

    3. NM_064586.4 → NP_496987.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62332
      Conserved Domains (2) summary
      COG5215
      Location:15 → 758
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:388 → 416
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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