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    cchl-1 putative holocytochrome-c-type synthase [ Caenorhabditis elegans ]

    Gene ID: 174713, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cchl-1
    Official Full Name
    putative holocytochrome-c-type synthase
    Primary source
    WormBase:WBGene00011527
    Locus tag
    CELE_T06D8.6
    See related
    AllianceGenome:WB:WBGene00011527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable holocytochrome-c synthase activity. Predicted to be involved in cytochrome c-heme linkage. Located in mitochondrion. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Orthologous to human HCCS (holocytochrome c synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See cchl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (11235052..11236387, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Neighboring gene ncRNA Neighboring gene UVR domain-containing protein Neighboring gene EOG090X04TT Neighboring gene FUN14 domain-containing protein fndc-1 Neighboring gene ncRNA Neighboring gene 26S proteasome non-ATPase regulatory subunit 13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Yoon JC, et al. Proc Natl Acad Sci U S A, 2014 Mar 11. PMID 24556985, Free PMC Article
    2. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. Hansen M, et al. PLoS Genet, 2005 Jul. PMID 16103914, Free PMC Article
    3. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article
    4. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables holocytochrome-c synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables holocytochrome-c synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative holocytochrome-c-type synthase
    NP_496403.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11235052..11236387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064002.8 → NP_496403.1  putative holocytochrome-c-type synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496403.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53703
      Conserved Domains (1) summary
      pfam01265
      Location:34 → 251
      Cyto_heme_lyase; Cytochrome c/c1 heme lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53703.1

    Gene LinkOut

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