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    vps-11 Vacuolar protein sorting-associated protein 11 homolog [ Caenorhabditis elegans ]

    Gene ID: 174661, updated on 18-Sep-2024

    Summary

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    Official Symbol
    vps-11
    Official Full Name
    Vacuolar protein sorting-associated protein 11 homolog
    Primary source
    WormBase:WBGene00011067
    Locus tag
    CELE_R06F6.2
    See related
    AllianceGenome:WB:WBGene00011067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in several processes, including endosome organization; vacuole organization; and vesicle docking involved in exocytosis. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be part of HOPS complex. Predicted to be active in endosome. Is expressed in gonad. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See vps-11 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (10788106..10793493, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Histone RNA hairpin-binding protein Neighboring gene Putative protein tag-209 Neighboring gene SET domain-containing protein 14 Neighboring gene Nucleoporin NUP35

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans. Xiao H, et al. Mol Biol Cell, 2009 Jan. PMID 18923146, Free PMC Article
    2. ccz-1 mediates the digestion of apoptotic corpses in C. elegans. Nieto C, et al. J Cell Sci, 2010 Jun 15. PMID 20519582
    3. Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1. Delahaye JL, et al. Mol Biol Cell, 2014 Apr. PMID 24501423, Free PMC Article
    4. Identification of the switch in early-to-late endosome transition. Poteryaev D, et al. Cell, 2010 Apr 30. PMID 20434987
    5. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuole organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HOPS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vesicle tethering complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar protein sorting-associated protein 11 homolog
    NP_496322.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10788106..10793493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063921.7 → NP_496322.2  Vacuolar protein sorting-associated protein 11 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496322.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09600
      Conserved Domains (4) summary
      smart00299
      Location:407 → 531
      CLH; Clathrin heavy chain repeat homology
      cd00162
      Location:802 → 845
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam00637
      Location:413 → 531
      Clathrin; Region in Clathrin and VPS
      pfam12451
      Location:840 → 882
      VPS11_C; Vacuolar protein sorting protein 11 C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09600.2

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    Chemical Information
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