mpz-1 PDZ domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mpz-1
Official Full Name: PDZ domain-containing protein
Primary source: WormBase:WBGene00003404
Locus tag: CELE_C52A11.4
See related: AllianceGenome:WB:WBGene00003404
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activating protein binding activity. Located in axon. Is expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Orthologous to several human genes including MPDZ (multiple PDZ domain crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See mpz-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 44

Sequence:: Chromosome: II; NC_003280.10 (10738635..10778126, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These observations indicate neuronally expressed RHGF-2 is an essential RHO-1 specific RhoGEF that binds most strongly to MPZ-1 PDZ domain eight and is required for wild-type C. elegans morphology and growth.
Title: RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.
results suggest that the ARR-1-MPZ-1-DAF-18 complex functions to regulate DAF-2 signaling in vivo and provide insight into a novel mechanism by which arrestin is able to regulate IGF-1R signaling and longevity
Title: Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.
These studies suggest that the SER-1/MPZ-1 interaction facilitates SER-1 mediated signaling.
Title: SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T19E10.2 (e-PCR)
- UniSTS:322322

C52A11.4 (e-PCR)
- UniSTS:321301

STS2-187 (e-PCR)
- UniSTS:241859

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PDZ domain-containing protein

NP_001022038.2

Confirmed by transcript evidence

NP_001022039.2

Confirmed by transcript evidence

NP_001076626.2

Confirmed by transcript evidence

NP_001122599.1

Confirmed by transcript evidence

NP_001122601.1

Confirmed by transcript evidence

NP_001254262.1

Confirmed by transcript evidence

NP_001254263.1

Confirmed by transcript evidence

NP_001254264.1

Confirmed by transcript evidence

NP_001364655.1

Partially confirmed by transcript evidence

NP_001364657.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10738635..10778126 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026867.4 → NP_001022038.2 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022038.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EC55, Q0PJA9

Conserved Domains (2) summary

smart00228
Location:1959 → 2044

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1446 → 1540

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001377854.2 → NP_001364657.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EC95, Q0PJA9

Conserved Domains (2) summary

smart00228
Location:1959 → 2044

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1446 → 1540

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001377853.2 → NP_001364655.1 PDZ domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5ECZ8, Q0PJA9

Conserved Domains (2) summary

smart00228
Location:1988 → 2073

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1475 → 1569

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001129129.4 → NP_001122601.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122601.1

Status: REVIEWED

UniProtKB/TrEMBL

G5ECF9, Q0PJA9

Conserved Domains (2) summary

smart00228
Location:1750 → 1835

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1237 → 1331

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001129127.4 → NP_001122599.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122599.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EGP5, Q0PJA9

Conserved Domains (2) summary

smart00228
Location:1750 → 1835

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1237 → 1331

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001083157.4 → NP_001076626.2 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076626.2

Status: REVIEWED

UniProtKB/TrEMBL

Q09EF4, Q0PJA9

Conserved Domains (2) summary

smart00228
Location:1768 → 1853

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1255 → 1349

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001267333.3 → NP_001254262.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254262.1

Status: REVIEWED

UniProtKB/TrEMBL

G1K0W4

Conserved Domains (2) summary

smart00228
Location:975 → 1060

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:462 → 556

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001267334.3 → NP_001254263.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254263.1

Status: REVIEWED

UniProtKB/TrEMBL

G1K0W3

Conserved Domains (2) summary

smart00228
Location:546 → 631

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:33 → 127

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001267335.3 → NP_001254264.1 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001254264.1

Status: REVIEWED

UniProtKB/TrEMBL

G1K0W2

Conserved Domains (2) summary

smart00228
Location:36 → 121

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:137 → 217

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001026868.5 → NP_001022039.2 PDZ domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022039.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EDY4

Conserved Domains (1) summary

cd00992
Location:510 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...