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    fkh-8 Fork-head domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174026, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fkh-8
    Official Full Name
    Fork-head domain-containing protein
    Primary source
    WormBase:WBGene00001440
    Locus tag
    CELE_F40H3.4
    See related
    AllianceGenome:WB:WBGene00001440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in neurons. Orthologous to human FOXR1 (forkhead box R1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See fkh-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (6189623..6191393, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cytoplasmic polyadenylation element-binding protein 2 Neighboring gene RRM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions. Didiano D, et al. Nat Struct Mol Biol, 2006 Sep. PMID 16921378
    2. The forkhead gene family of Caenorhabditis elegans. Hope IA, et al. Gene, 2003 Jan 30. PMID 12568714
    3. PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Panowski SH, et al. Nature, 2007 May 31. PMID 17476212
    4. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
    5. The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Etchberger JF, et al. Genes Dev, 2007 Jul 1. PMID 17606643, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans.
      Title: Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fork-head domain-containing protein
    NP_001254107.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6189623..6191393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267178.4 → NP_001254107.1  Fork-head domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZ39
      Conserved Domains (2) summary
      smart00339
      Location:74 → 156
      FH; FORKHEAD
      COG5025
      Location:30 → 217
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
    Nucleotide Protein
    Heading Accession and Version

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