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    gcy-12 Receptor-type guanylate cyclase gcy-12 [ Caenorhabditis elegans ]

    Gene ID: 173902, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gcy-12
    Official Full Name
    Receptor-type guanylate cyclase gcy-12
    Primary source
    WormBase:WBGene00001538
    Locus tag
    CELE_F08B1.2
    See related
    AllianceGenome:WB:WBGene00001538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables guanylate cyclase activity. Involved in negative regulation of dauer larval development; regulation of growth; and regulation of locomotion involved in locomotory behavior. Located in dendrite; non-motile cilium; and perikaryon. Is expressed in excretory gland cell; ganglia; head muscle; and head neurons. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See gcy-12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    16
    Sequence:
    Chromosome: II; NC_003280.10 (5312046..5319617)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein kinase Neighboring gene ncRNA Neighboring gene Dual specificity protein phosphatase 7;Tyrosine-protein phosphatase vhp-1;protein-tyrosine-phosphatase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans. Fujiwara M, et al. PLoS Genet, 2010 Nov 24. PMID 21124861, Free PMC Article
    2. The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans. Fujiwara M, et al. Genetics, 2015 Dec. PMID 26434723, Free PMC Article
    3. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Yu S, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096403, Free PMC Article
    4. The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor. Baude EJ, et al. J Biol Chem, 1997 Jun 20. PMID 9188508
    5. Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Inada H, et al. Genetics, 2006 Apr. PMID 16415369, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-12
    NP_494995.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5312046..5319617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062594.3 → NP_494995.2  Receptor-type guanylate cyclase gcy-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494995.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19187
      Conserved Domains (7) summary
      cd06370
      Location:123 → 545
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00219
      Location:688 → 951
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:991 → 1183
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:648 → 957
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:1018 → 1206
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:140 → 519
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:967 → 1012
      HNOBA; Heme NO binding associated

    RNA

    1. NR_134556.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19187.3

    Gene LinkOut

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