sgt-1 SGTA homodimerization domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sgt-1
Official Full Name: SGTA homodimerization domain-containing protein
Primary source: WormBase:WBGene00019893
Locus tag: CELE_R05F9.10
See related: AllianceGenome:WB:WBGene00019893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable molecular adaptor activity. Predicted to be involved in posttranslational protein targeting to endoplasmic reticulum membrane and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in body wall musculature; intestine; and pharynx. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha) and SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See sgt-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 3

Sequence:: Chromosome: II; NC_003280.10 (4902288..4903796, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sgt-1,the putative Caenorhabditis elegans orthologue for small glutamine-rich tetratricopeptide repeat-containing protein, was cloned and characterized.
Title: Cloning, purification and characterization of the Caenorhabditis elegans small glutamine-rich tetratricopeptide repeat-containing protein.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R05F9.10 (e-PCR)
- UniSTS:312052

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TRC complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SGTA homodimerization domain-containing protein

NP_494893.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4902288..4903796 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062492.8 → NP_494893.1 SGTA homodimerization domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494893.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21746

Conserved Domains (5) summary

smart00028
Location:138 → 171

TPR; Tetratricopeptide repeats

sd00006
Location:105 → 133

TPR; TPR repeat [structural motif]

pfam00515
Location:172 → 204

TPR_1; Tetratricopeptide repeat

pfam13414
Location:104 → 169

TPR_11; TPR repeat

pfam16546
Location:25 → 83

SGTA_dimer; Homodimerization domain of SGTA