U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    dnj-29 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173278, updated on 17-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dnj-29
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00001047
    Locus tag
    CELE_Y63D3A.6
    See related
    AllianceGenome:WB:WBGene00001047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in posttranslational protein targeting to membrane, translocation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in polycystic liver disease. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dnj-29 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (14104515..14113108, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene 5'-tyrosyl-DNA phosphodiesterase Neighboring gene Protein tfg-1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 Neighboring gene TLC domain-containing protein fld-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Analysis of long-lived C. elegans daf-2 mutants using serial analysis of gene expression. Halaschek-Wiener J, et al. Genome Res, 2005 May. PMID 15837805, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    J domain-containing protein
    NP_001369819.1
    • Confirmed by transcript evidence
    NP_493464.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14104515..14113108 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383758.2 → NP_001369819.1  J domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1V9
      Conserved Domains (2) summary
      smart00611
      Location:212 → 713
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:107 → 165
      DnaJ; DnaJ domain

    2. NM_061063.5 → NP_493464.1  J domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493464.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1W0
      Conserved Domains (2) summary
      smart00611
      Location:212 → 483
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:107 → 165
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools