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    aex-6 small monomeric GTPase [ Caenorhabditis elegans ]

    Gene ID: 173223, updated on 18-Sep-2024

    Summary

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    Official Symbol
    aex-6
    Official Full Name
    small monomeric GTPase
    Primary source
    WormBase:WBGene00000089
    Locus tag
    CELE_Y87G2A.4
    See related
    AllianceGenome:WB:WBGene00000089
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity. Involved in exocytosis; positive regulation of cellular protein catabolic process; and positive regulation of defecation. Located in synaptic vesicle. Is expressed in intestine and neurons. Human ortholog(s) of this gene implicated in Griscelli syndrome type 2 and non-Langerhans-cell histiocytosis. Orthologous to several human genes including RAB27A (RAB27A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See aex-6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (13543068..13545188, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Acyl-coenzyme A thioesterase 8 Neighboring gene ncRNA Neighboring gene Cysteine protease atg-4.1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Valine--tRNA ligase Neighboring gene Carbohydrate sulfotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans. Lin-Moore AT, et al. PLoS Genet, 2021 Nov. PMID 34818334, Free PMC Article
    2. RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans. Feng W, et al. Sci China Life Sci, 2012 Mar. PMID 22527519
    3. Caenorhabditis elegans Rab escort protein (REP-1) differently regulates each Rab protein function and localization in a tissue-dependent manner. Tanaka D, et al. Genes Cells, 2008 Nov. PMID 19090809
    4. HID-1, a new component of the peptidergic signaling pathway. Mesa R, et al. Genetics, 2011 Feb. PMID 21115972, Free PMC Article
    5. Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Mahoney TR, et al. Mol Biol Cell, 2006 Jun. PMID 16571673, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
      Title: rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
    2. RAB-27/AEX-6 is involved in the tethering of DCVs and its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking
      Title: RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dense core granule exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle tethering involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small monomeric GTPase
    NP_493376.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13543068..13545188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060975.6 → NP_493376.1  small monomeric GTPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493376.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBS5, I7FXD9
      Conserved Domains (2) summary
      cd04127
      Location:4 → 182
      Rab27A; Rab GTPase family 27a (Rab27a)
      pfam00071
      Location:9 → 180
      Ras; Ras family
    Nucleotide Protein
    Heading Accession and Version

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