gld-1 Female germline-specific tumor suppressor gld-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gld-1
Official Full Name: Female germline-specific tumor suppressor gld-1
Primary source: WormBase:WBGene00001595
Locus tag: CELE_T23G11.3
See related: AllianceGenome:WB:WBGene00001595
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mRNA 3'-UTR binding activity; mRNA 5'-UTR binding activity; and single-stranded RNA binding activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of female gonad development; and positive regulation of oocyte development. Located in P granule and cytosol. Is expressed in several structures, including AB; C; germ line; oocyte; and ventral nerve cord. Orthologous to human QKI (QKI, KH domain containing RNA binding). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See gld-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (7695681..7698222)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-84 is a specific interactor of the gld-1 transcript.
Title: Identification of proteins and miRNAs that specifically bind an mRNA in vivo.
Block III (21 RNAs) was enriched for RNA-binding proteins, including previously validated FBF targets gld-1 and htp-1 We suggest that Block I RNAs belong to the FBF network for spermatogenesis, and that Blocks II and III are associated with stem cell functions.
Title: Toward Identifying Subnetworks from FBF Binding Landscapes in Caenorhabditis Spermatogenic or Oogenic Germlines.
Data suggest the female germline-specific tumor suppressor gld-1 (GLD-1)-feminization Of Germline FOG-2 protein (FOG-2) complex regulates uncharacterized sites within tra-2, or other mRNA targets.
Title: Multi-modal regulation of C. elegans hermaphrodite spermatogenesis by the GLD-1-FOG-2 complex.
GLD-1 expression and degradation during oocyte meiotic progression.
Title: MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression.
glp-1 transcriptional targets lst-1 and sygl-1 are individually required for GLD-1 repression in stem cells; regulation of GLD-1 levels and pattern appears regional in the proliferative zone
Title: Germline Stem Cell Differentiation Entails Regional Control of Cell Fate Regulator GLD-1 in Caenorhabditis elegans.
Gld-1; puf-8 double-mutant germ cells begin to express the meiotic marker HIM-3, lose P granules, and form the sperm-specific membranous organelle, which are characteristics of developing spermatocytes.
Title: PUF-8 Functions Redundantly with GLD-1 to Promote the Meiotic Progression of Spermatocytes in Caenorhabditis elegans.
We examine GLD-1-binding motifs among targets conserved in C. elegans and C. briggsae and find that most, but not all, display evidence of shared ancestral binding sites.
Title: Evolutionary Dynamics of GLD-1-mRNA complexes in Caenorhabditis nematodes.
The study demonstrates that the QUA2 domain distinguishes GLD-1 from other members of the STAR family and contributes more generally to the modulation of RNA-binding affinity and specificity of KH domain containing proteins.
Title: Structural and functional implications of the QUA2 domain on RNA recognition by GLD-1.
Results show the RNA-binding protein GLD-1 in C. elegans affects multiple microRNA pathways and interacts with proteins required for microRNA function.
Title: RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans.
Our results demonstrate that both proteins recognize the glp-1 3' untranslated region (UTR) through adjacent, overlapping binding sites and that POS-1 binding excludes GLD-1 binding
Title: POS-1 and GLD-1 repress glp-1 translation through a conserved binding-site cluster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23G11.3 (e-PCR)
- UniSTS:308090

T23G11.4 (e-PCR)
- UniSTS:307118

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of female gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in post-transcriptional regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of germ cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Female germline-specific tumor suppressor gld-1

NP_492143.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

7695681..7698222

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059742.8 → NP_492143.1 Female germline-specific tumor suppressor gld-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492143.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02540, Q17339

Conserved Domains (2) summary

cd02395
Location:206 → 328

SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...

pfam16544
Location:144 → 190

STAR_dimer; Homodimerization region of STAR domain protein