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    sol-1 Suppressor of lurcher protein 1 [ Caenorhabditis elegans ]

    Gene ID: 172493, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sol-1
    Official Full Name
    Suppressor of lurcher protein 1
    Primary source
    WormBase:WBGene00004944
    Locus tag
    CELE_C15A11.3
    See related
    AllianceGenome:WB:WBGene00004944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables channel regulator activity. Involved in several processes, including hyperosmotic response; positive regulation of glutamatergic synaptic transmission; and thigmotaxis. Located in neuron projection membrane and synapse. Part of ionotropic glutamate receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See sol-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (7389054..7395918, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein PXR1-like Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Cuticle collagen 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans. Zheng Y, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418277, Free PMC Article
    2. SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans. Zheng Y, et al. Nature, 2004 Jan 29. PMID 14749834
    3. SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction. Wang ZW, et al. Neuron, 2001 Dec 6. PMID 11738032
    4. Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function. Wang R, et al. Neuron, 2008 Sep 25. PMID 18817737, Free PMC Article
    5. Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Walker CS, et al. Proc Natl Acad Sci U S A, 2006 Jul 11. PMID 16818875, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SOL-1 is an accessory protein that is selectively required for glutamate-gated currents
      Title: SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans.
    2. SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors
      Title: SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables channel regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in thigmotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Suppressor of lurcher protein 1
    NP_492088.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7389054..7395918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059687.8 → NP_492088.3  Suppressor of lurcher protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492088.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93212
      Conserved Domains (3) summary
      smart00042
      Location:447 → 551
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      cd00041
      Location:298 → 416
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cl00049
      Location:28 → 144
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93212.3

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