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    prpf-4 Protein kinase domain-containing protein;Serine/threonine-protein kinase PRP4 homolog [ Caenorhabditis elegans ]

    Gene ID: 172443, updated on 18-Sep-2024

    Summary

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    Official Symbol
    prpf-4
    Official Full Name
    Protein kinase domain-containing protein;Serine/threonine-protein kinase PRP4 homolog
    Primary source
    WormBase:WBGene00004186
    Locus tag
    CELE_F22D6.5
    See related
    AllianceGenome:WB:WBGene00004186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in nucleus. Orthologous to human PRPF4B (pre-mRNA processing factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See prpf-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (7091309..7094538, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene AN1-type domain-containing protein Neighboring gene Asparagine--tRNA ligase, cytoplasmic Neighboring gene putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial Neighboring gene ncRNA Neighboring gene Tudor domain-containing protein Neighboring gene pseudo Neighboring gene 40S ribosomal protein S25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein. Basson M, et al. Genes Dev, 1996 Aug 1. PMID 8756352
    2. Genetic and molecular analysis of the dpy-14 region in Caenorhabditis elegans. McKim KS, et al. Mol Gen Genet, 1992 May. PMID 1603066
    3. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
    4. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
    5. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein kinase domain-containing protein;Serine/threonine-protein kinase PRP4 homolog
    NP_001250391.1
    • Confirmed by transcript evidence
    NP_001250392.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7091309..7094538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001263463.4 → NP_001250392.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W737
      Conserved Domains (1) summary
      cl21453
      Location:454 → 740
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001263462.5 → NP_001250391.1  Serine/threonine-protein kinase PRP4 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001250391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19727
      Conserved Domains (1) summary
      cd14135
      Location:454 → 770
      STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
    Nucleotide Protein
    Heading Accession and Version

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