msh-2 DNA mismatch repair proteins mutS family domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: msh-2
Official Full Name: DNA mismatch repair proteins mutS family domain-containing protein
Primary source: WormBase:WBGene00003418
Locus tag: CELE_H26D21.2
See related: AllianceGenome:WB:WBGene00003418
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP-dependent activity, acting on DNA and double-strand/single-strand DNA junction binding activity. Predicted to contribute to DNA binding activity and MutLalpha complex binding activity. Involved in DNA metabolic process; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and reproduction. Predicted to be located in nucleus. Predicted to be part of MutSalpha complex and MutSbeta complex. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See msh-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (3694296..3697551, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation rate and spectrum in obligately outcrossing Caenorhabditis elegans mutation accumulation lines subjected to RNAi-induced knockdown of the mismatch repair gene msh-2.
Title: Mutation rate and spectrum in obligately outcrossing Caenorhabditis elegans mutation accumulation lines subjected to RNAi-induced knockdown of the mismatch repair gene msh-2.
Divergence experiments were conducted on msh-2 in a range of population sizes. Mutational variance is dominated by contributions from highly detrimental mutations.
Title: Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegans.
MMR surveillance is carried out by a single Msh-2/Msh-6 heterodimer
Title: Mutation rates, spectra and hotspots in mismatch repair-deficient Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H26D21.1 (e-PCR)
- UniSTS:317390

H26D21.2 (e-PCR)
- UniSTS:317391

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-strand/single-strand DNA junction binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables mismatched DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of DNA repeat elements	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IEA Inferred from Electronic Annotation more info
involved_in mismatch repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MutSalpha complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MutSalpha complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA mismatch repair proteins mutS family domain-containing protein

NP_491202.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3694296..3697551 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058801.8 → NP_491202.1 DNA mismatch repair proteins mutS family domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491202.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9TXR4

Conserved Domains (1) summary

COG0249
Location:17 → 847

MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]