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    Syt12 synaptotagmin XII [ Mus musculus (house mouse) ]

    Gene ID: 171180, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Syt12provided by MGI
    Official Full Name
    synaptotagmin XIIprovided by MGI
    Primary source
    MGI:MGI:2159601
    See related
    Ensembl:ENSMUSG00000049303 AllianceGenome:MGI:2159601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Involved in long-term synaptic potentiation and presynaptic modulation of chemical synaptic transmission. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Colocalizes with synaptic vesicle. Is expressed in adrenal gland and ventral grey horn. Orthologous to human SYT12 (synaptotagmin 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 26.5), genital fat pad adult (RPKM 23.5) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syt12 in Genome Data Viewer
    Location:
    19 A; 19 4.07 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4495936..4527171, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4445908..4477143, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 2A Neighboring gene RIKEN cDNA 9430078G10 gene Neighboring gene STARR-positive B cell enhancer ABC_E1521 Neighboring gene STARR-seq mESC enhancer starr_45348 Neighboring gene RIKEN cDNA A930001C03 gene Neighboring gene STARR-seq mESC enhancer starr_45349 Neighboring gene ras homolog family member D Neighboring gene RIKEN cDNA 2010003K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E778 Neighboring gene STARR-seq mESC enhancer starr_45350 Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mechanism of the SDS-resistant synaptotagmin clustering mediated by the cysteine cluster at the interface between the transmembrane and spacer domains. Fukuda M, et al. J Biol Chem, 2001 Oct 26. PMID 11514560
    2. Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. Kaeser-Woo YJ, et al. J Neurosci, 2013 Jun 5. PMID 23739973, Free PMC Article
    3. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. Maximov A, et al. J Cell Biol, 2007 Jan 1. PMID 17190793, Free PMC Article
    4. Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Fukuda M. Neuroreport, 2006 Feb 6. PMID 16407767
    5. Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage. Yao W, et al. J Neurosci, 2019 Aug 28. PMID 31235642, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Synaptotagmin-12 is essential for cyclic AMP-dependent protein kinase presynaptic long term potentiation at mossy-fiber synapses.
      Title: Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion sensor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spontaneous exocytosis of neurotransmitter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with hippocampal mossy fiber to CA3 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptotagmin-12
    Names
    sytXII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134164.5 → NP_598925.1  synaptotagmin-12

      See identical proteins and their annotated locations for NP_598925.1

      Status: VALIDATED

      Source sequence(s)
      AC124347
      Consensus CDS
      CCDS29428.1
      UniProtKB/Swiss-Prot
      Q920N7
      UniProtKB/TrEMBL
      Q14AG7
      Related
      ENSMUSP00000055237.4, ENSMUST00000059295.10
      Conserved Domains (2) summary
      cd08406
      Location:284 → 419
      C2B_Synaptotagmin-12; C2 domain second repeat present in Synaptotagmin 12
      cl14603
      Location:152 → 263
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4495936..4527171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920N7.1 GenPept UniProtKB/Swiss-Prot:Q920N7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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