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    Mutyh mutY DNA glycosylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170841, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Mutyhprovided by RGD
    Official Full Name
    mutY DNA glycosylaseprovided by RGD
    Primary source
    RGD:620045
    See related
    EnsemblRapid:ENSRNOG00000017887 AllianceGenome:RGD:620045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Myh
    Summary
    Enables DNA N-glycosylase activity. Involved in response to oxidative stress. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 94.0), Spleen (RPKM 54.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mutyh in Genome Data Viewer
    Location:
    5q35
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135510666..135522777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130274034..130286149)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135663328..135675348)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene metabolism of cobalamin associated C Neighboring gene coiled-coil domain containing 163 Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene ribosomal protein S26 like 4 Neighboring gene target of EGR1, exonuclease Neighboring gene 4-hydroxyphenylpyruvate dioxygenase-like Neighboring gene ribosomal protein S20, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain. Lee HM, et al. J Neurochem, 2004 Jan. PMID 14690527
    2. Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria. Englander EW, et al. J Neurochem, 2002 Dec. PMID 12472901
    3. MutY DNA Glycosylase Protects Cells From Tumor Necrosis Factor Alpha-Induced Necroptosis. Tran AHV, et al. J Cell Biochem, 2017 Jul. PMID 28059467
    4. Adenine DNA glycosylase activity of 14 human MutY homolog (MUTYH) variant proteins found in patients with colorectal polyposis and cancer. Goto M, et al. Hum Mutat, 2010 Nov. PMID 20848659, Free PMC Article
    5. Genetic alterations of the MYH gene in gastric cancer. Kim CJ, et al. Oncogene, 2004 Sep 2. PMID 15273732

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. respiratory hypoxia leads to increased expression of MYH in the rat brain
      Title: Hypoxia induces mitochondrial DNA damage and stimulates expression of a DNA repair enzyme, the Escherichia coli MutY DNA glycosylase homolog (MYH), in vivo, in the rat brain.
    2. Levels of MutY DNA glycosylase are detected in rat brain at the embryonic stage, decrease during embryonic and neonatal development, while new isoforms appear and gradually increase in the neonate and adult brain.
      Title: Developmental changes in expression and subcellular localization of the DNA repair glycosylase, MYH, in the rat brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156598

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables MutLalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables MutLbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MutSalpha complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables MutSbeta complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenine/guanine mispair binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidized purine DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-specific mismatch base pair DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-specific mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine-specific mismatch base pair DNA N-glycosylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables purine-specific mismatch base pair DNA N-glycosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenine DNA glycosylase
    Names
    a/G-specific adenine DNA glycosylase
    mutY homolog
    rMYH
    NP_579850.2
    XP_038965128.1
    XP_038965129.1
    XP_038965130.1
    XP_038965131.1
    XP_038965132.1
    XP_038965133.1
    XP_038965135.1
    XP_038965136.1
    XP_063143179.1
    XP_063143180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133316.2 → NP_579850.2  adenine DNA glycosylase

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q8R5G2
      UniProtKB/TrEMBL
      A6JZA6, G3V8C1
      Related
      ENSRNOP00000083752.1, ENSRNOT00000118511.2
      Conserved Domains (1) summary
      COG1194
      Location:63 → 463
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135510666..135522777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109200.2 → XP_038965128.1  adenine DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      Q8R5G2
      Conserved Domains (1) summary
      COG1194
      Location:63 → 470
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    2. XM_039109202.2 → XP_038965130.1  adenine DNA glycosylase isoform X2

      UniProtKB/Swiss-Prot
      Q8R5G2
      Conserved Domains (1) summary
      COG1194
      Location:63 → 432
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    3. XM_063287109.1 → XP_063143179.1  adenine DNA glycosylase isoform X3

      UniProtKB/Swiss-Prot
      Q8R5G2

    4. XM_039109208.2 → XP_038965136.1  adenine DNA glycosylase isoform X8

      Conserved Domains (1) summary
      COG1194
      Location:63 → 282
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    5. XM_039109207.2 → XP_038965135.1  adenine DNA glycosylase isoform X7

      Conserved Domains (1) summary
      COG1194
      Location:63 → 293
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    6. XM_039109201.2 → XP_038965129.1  adenine DNA glycosylase isoform X1

      UniProtKB/Swiss-Prot
      Q8R5G2
      Conserved Domains (1) summary
      COG1194
      Location:63 → 470
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    7. XM_039109203.2 → XP_038965131.1  adenine DNA glycosylase isoform X4

      Conserved Domains (1) summary
      COG1194
      Location:1 → 364
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    8. XM_039109204.2 → XP_038965132.1  adenine DNA glycosylase isoform X5

      Conserved Domains (1) summary
      COG1194
      Location:1 → 347
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    9. XM_063287110.1 → XP_063143180.1  adenine DNA glycosylase isoform X6

    10. XM_039109205.2 → XP_038965133.1  adenine DNA glycosylase isoform X5

      Conserved Domains (1) summary
      COG1194
      Location:1 → 347
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]

    RNA

    1. XR_010066340.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5G2.1 GenPept UniProtKB/Swiss-Prot:Q8R5G2

    Gene LinkOut

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