Fgf23 fibroblast growth factor 23 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgf23provided by RGD
Official Full Name: fibroblast growth factor 23provided by RGD
Primary source: RGD:620178
See related: EnsemblRapid:ENSRNOG00000066556 AllianceGenome:RGD:620178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fgf8b
Summary: Predicted to enable growth factor activity and type 1 fibroblast growth factor receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to interleukin-6; and cellular response to vitamin D. Located in extracellular space. Biomarker of chronic kidney disease and uremia. Human ortholog(s) of this gene implicated in autosomal dominant hypophosphatemic rickets. Orthologous to human FGF23 (fibroblast growth factor 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 4.6), Spleen (RPKM 0.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (161600439..161609991)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (159914267..159923821)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (159622404..159630082)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation.
Title: Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation.
ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats.
Title: ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats.
Changes of FGF23 and hearing in chronic renal failure and their correlation analysis.
Title: Changes of FGF23 and hearing in chronic renal failure and their correlation analysis.
Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway.
Title: Klotho/FGF23 Axis Regulates Cardiomyocyte Apoptosis and Cytokine Release through ERK/MAPK Pathway.
Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney Disease-Induced Myocardial Fibrosis by Activating the Sonic Hedgehog Signaling Pathway.
Title: Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney Disease-Induced Myocardial Fibrosis by Activating the Sonic Hedgehog Signaling Pathway.
Renal Clearance of Fibroblast Growth Factor-23 (FGF23) and its Fragments in Humans.
Title: Renal Clearance of Fibroblast Growth Factor-23 (FGF23) and its Fragments in Humans.
The synthesis of fibroblast growth factor 23 is upregulated by homocysteine in UMR106 osteoblast-like cells.
Title: The synthesis of fibroblast growth factor 23 is upregulated by homocysteine in UMR106 osteoblast-like cells.
Lactic acid induces fibroblast growth factor 23 (FGF23) production in UMR106 osteoblast-like cells.
Title: Lactic acid induces fibroblast growth factor 23 (FGF23) production in UMR106 osteoblast-like cells.
Oral Acid Load Down-Regulates Fibroblast Growth Factor 23.
Title: Oral Acid Load Down-Regulates Fibroblast Growth Factor 23.
Up-Regulation of Fibroblast Growth Factor 23 Gene Expression in UMR106 Osteoblast-like Cells with Reduced Viability.
Title: Up-Regulation of Fibroblast Growth Factor 23 Gene Expression in UMR106 Osteoblast-like Cells with Reduced Viability.

Submit: New GeneRIF Correction See all GeneRIFs (57)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to leptin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sodium phosphate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
involved_in vitamin D catabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin D metabolic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibroblast growth factor 23

Names: FGF-23; fibroblast growth factor 8b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130754.2 → NP_570110.1 fibroblast growth factor 23 precursor

See identical proteins and their annotated locations for NP_570110.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q8VI82

UniProtKB/TrEMBL

A6ILX1

Related

ENSRNOP00000087703.2, ENSRNOT00000107111.2

Conserved Domains (1) summary

cl00060
Location:41 → 160

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...