Klra7 killer cell lectin-like receptor, subfamily A, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klra7provided by MGI
Official Full Name: killer cell lectin-like receptor, subfamily A, member 7provided by MGI
Primary source: MGI:MGI:101901
See related: Ensembl:ENSMUSG00000067599 AllianceGenome:MGI:101901
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LGL-1; Ly49g; Ly49g1; Ly49g2; Ly49G.4; Ly-49G.1; Ly-49G.2; Ly-49G.3
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in regulation of signal transduction. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.44 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (130195568..130210285, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (130218605..130233322, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ectodomain of inhibitory Ly49G of the BALB/c mouse strain is highly similar to the Ly49W activating receptor in the nonobese diabetic (NOD) mouse.
Title: The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.
High levels of Ly49G2 have a dominant inhibitory effect on Ly49D expressed at low levels on immature bone marrow and mature B cells, resulting in inhibition of interferon-gamma secretion.
Title: Tight regulation of IFN-gamma transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2.
Allelic variation in Ly-49G2 extracellular domains has functional significance by altering Ly-49 receptor specificity for class I MHC and xenogeneic ligands.
Title: Allelic variation in the ectodomain of the inhibitory Ly-49G2 receptor alters its specificity for allogeneic and xenogeneic ligands.
Glycosylation of Ly-49G2 at amino acid residues NTT221-23 reduces receptor binding to H-2Dd tetramers and may represent a mechanism by which natural killer cells regulate affinity for host class I ligands.
Title: Receptor glycosylation regulates Ly-49 binding to MHC class I.
The repertoire of inhibitory Ly49 receptors may be formed under the influenced of Fyn-dependent NK cell activation as well as the respective MHC class I environment.
Title: A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491533

G54774 (e-PCR)
- UniSTS:117857

Klra7 (e-PCR), detects polymorphism
- UniSTS:143715

Klra7 (e-PCR), detects polymorphism
- UniSTS:143716

Klra7 (e-PCR), detects polymorphism
- UniSTS:143717

NoName (e-PCR)
- UniSTS:495509

NoName (e-PCR)
- UniSTS:489145

NoName (e-PCR)
- UniSTS:489197

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor 7

Names: T-cell surface glycoprotein Ly-49G; ly-49g; lymphocyte antigen 49g

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110323.1 → NP_001103793.1 killer cell lectin-like receptor 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC161448, U10093

Consensus CDS

CCDS51928.1

UniProtKB/Swiss-Prot

Q60654, Q60655, Q60656, Q60683

UniProtKB/TrEMBL

F8WJ94

Related

ENSMUSP00000032286.7, ENSMUST00000032286.7

Conserved Domains (2) summary

cd03593
Location:158 → 273

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 171

Ly49; Ly49-like protein, N-terminal region
NM_014194.5 → NP_055009.5 killer cell lectin-like receptor 7 isoform 2

See identical proteins and their annotated locations for NP_055009.5

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' and 3' UTR and lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

U10094

Consensus CDS

CCDS39668.1

UniProtKB/TrEMBL

Q9EP76

Related

ENSMUSP00000037917.8, ENSMUST00000049304.14

Conserved Domains (2) summary

cd03593
Location:145 → 260

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

pfam08391
Location:40 → 158

Ly49; Ly49-like protein, N-terminal region