DCN decorin [Homo sapiens (human)] - Gene

Summary

Official Symbol: DCNprovided by HGNC
Official Full Name: decorinprovided by HGNC
Primary source: HGNC:HGNC:2705
See related: Ensembl:ENSG00000011465 MIM:125255; AllianceGenome:HGNC:2705
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B
Summary: This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Expression: Broad expression in ovary (RPKM 562.9), gall bladder (RPKM 411.1) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q21.33

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (91140484..91182817, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (91117966..91160293, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (91534261..91576594, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decorin attenuates hypertrophic scar fibrosis via TGFbeta/Smad signalling.
Title: Decorin attenuates hypertrophic scar fibrosis via TGFβ/Smad signalling.
The effects of TGF-beta1 and IFN-alpha2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.
Title: The effects of TGF-β1 and IFN-α2b on decorin, decorin isoforms and type I collagen in hypertrophic scar dermal fibroblasts.
Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.
Title: Maternally Expressed Gene 3 Negatively Regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells.
The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
Title: The aberrant levels of decorin induce damages of human salivary gland epithelial cells and polarization of macrophages.
HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.
Title: HBx downregulated decorin and decorin-derived peptides inhibit the proliferation and tumorigenicity of hepatocellular carcinoma cells.
The levels of peripheral blood TNF-alpha, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.
Title: The levels of peripheral blood TNF-α, Decorin and neutrophils MAPK1 mRNA levels of patients with preeclampsia and their clinical significance.
Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.
Title: Resistance Exercise-Induced Increases in Muscle Myostatin mRNA and Protein Expression Are Subsequently Decreased in Circulation in the Presence of Increased Levels of the Extracellular Matrix Stabilizing Protein Decorin.
Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
Title: Decorin promotes decidual M1-like macrophage polarization via mitochondrial dysfunction resulting in recurrent pregnancy loss.
Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth.
Title: Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth.
Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.
Title: Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases.

Submit: New GeneRIF Correction See all GeneRIFs (190)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital stromal corneal dystrophy MedGen: C1864738 OMIM: 610048 GeneReviews: Congenital Stromal Corneal Dystrophy	not available

EBI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH41859 (e-PCR)
- UniSTS:64097

GDB:197931 (e-PCR)
- UniSTS:156007

RH68984 (e-PCR)
- UniSTS:46953

RH103594 (e-PCR)
- UniSTS:97919

MARC_12473-12474:997213223:1 (e-PCR)
- UniSTS:267426

WI-17110 (e-PCR)
- UniSTS:77474

SHGC-17552 (e-PCR)
- UniSTS:14758

GDB:384910 (e-PCR)
- UniSTS:157120

WI-20146 (e-PCR)
- UniSTS:70612

SHGC-53083 (e-PCR)
- UniSTS:19163

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info
enables extracellular matrix structural constituent conferring compression resistance	ISS Inferred from Sequence or Structural Similarity more info
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables glycosaminoglycan binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macroautophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mitochondrial depolarization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mitochondrial fission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
colocalizes_with collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: decorin

Names: bone proteoglycan II; dermatan sulphate proteoglycans II; proteoglycan core protein; small leucine-rich protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011672.2 RefSeqGene

Range

5000..47333

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001920.5 → NP_001911.1 decorin isoform a preproprotein

See identical proteins and their annotated locations for NP_001911.1

Status: REVIEWED

Description

Transcript Variant: This variant (A1) represents the longest transcript and encodes the longest isoform. Both variants A1 and A2 encode the same isoform (a).

Source sequence(s)

AC007115, AW444736, BM672011, BX094949, BX571756, CD689331

Consensus CDS

CCDS9039.1

UniProtKB/Swiss-Prot

P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9

UniProtKB/TrEMBL

Q6FH10

Related

ENSP00000052754.5, ENST00000052754.10

Conserved Domains (3) summary

sd00033
Location:62 → 82

LRR_RI; leucine-rich repeat [structural motif]

pfam01462
Location:54 → 80

LRRNT; Leucine rich repeat N-terminal domain

cl26018
Location:70 → 298

NEL; C-terminal novel E3 ligase, LRR-interacting
NM_133503.4 → NP_598010.1 decorin isoform a preproprotein

See identical proteins and their annotated locations for NP_598010.1

Status: REVIEWED

Description

Transcript Variant: This variant (A2) differs in the 5' UTR compared to variant A1. Both variants A1 and A2 encode the same isoform (a).

Source sequence(s)

AC007115, AW444736, BM672011, BX094949, BX571756

Consensus CDS

CCDS9039.1

UniProtKB/Swiss-Prot

P07585, Q9P0Z0, Q9P0Z1, Q9Y5N8, Q9Y5N9

UniProtKB/TrEMBL

Q6FH10

Conserved Domains (3) summary

sd00033
Location:62 → 82

LRR_RI; leucine-rich repeat [structural motif]

pfam01462
Location:54 → 80

LRRNT; Leucine rich repeat N-terminal domain

cl26018
Location:70 → 298

NEL; C-terminal novel E3 ligase, LRR-interacting
NM_133504.3 → NP_598011.1 decorin isoform b precursor

See identical proteins and their annotated locations for NP_598011.1

Status: REVIEWED

Description

Transcript Variant: This variant (B) differs in the 5' UTR and lacks two alternate exons in the coding region compared to variant A1. The encoded isoform (b) is shorter than isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.

Source sequence(s)

AC007115, AF138301, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244

Consensus CDS

CCDS9040.1

UniProtKB/Swiss-Prot

P07585

UniProtKB/TrEMBL

Q6FH10

Related

ENSP00000413723.2, ENST00000420120.6

Conserved Domains (4) summary

smart00013
Location:54 → 77

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:70 → 92

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:112 → 172

LRR_8; Leucine rich repeat

cl26793
Location:70 → 196

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
NM_133505.3 → NP_598012.1 decorin isoform c precursor

See identical proteins and their annotated locations for NP_598012.1

Status: REVIEWED

Description

Transcript Variant: This variant (C) differs in the 5' UTR and lacks three alternate exons in the coding region compared to variant A1. The encoded isoform (c) is shorter than isoform a. This isoform (c) may undergo proteolytic processing similar to isoform a.

Source sequence(s)

AC007115, AF138302, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244

Consensus CDS

CCDS9041.1

UniProtKB/TrEMBL

F8VNV6

Related

ENSP00000401021.1, ENST00000425043.5

Conserved Domains (3) summary

smart00013
Location:54 → 76

LRRNT; Leucine rich repeat N-terminal domain

sd00031
Location:76 → 99

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:74 → 134

LRR_8; Leucine rich repeat
NM_133506.3 → NP_598013.1 decorin isoform d precursor

See identical proteins and their annotated locations for NP_598013.1

Status: REVIEWED

Description

Transcript Variant: This variant (D) differs in the 5' UTR and lacks four alternate exons in the coding region compared to variant A1. The encoded isoform (d) is shorter than isoform a. This isoform (d) may undergo proteolytic processing similar to isoform a.

Source sequence(s)

AC007115, AF138303, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244

Consensus CDS

CCDS9042.1

UniProtKB/TrEMBL

A0A0S2Z3L8

Related

ENSP00000399815.2, ENST00000441303.6

Conserved Domains (3) summary

smart00013
Location:54 → 85

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:62 → 82

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:84 → 125

LRR_8; Leucine rich repeat
NM_133507.3 → NP_598014.1 decorin isoform e precursor

See identical proteins and their annotated locations for NP_598014.1

Status: REVIEWED

Description

Transcript Variant: This variant (E) differs in the 5' UTR and lacks five alternate exons in the coding region compared to variant A1. The encoded isoform (e) is shorter than isoform a. This isoform (e) may undergo proteolytic processing similar to isoform a.

Source sequence(s)

AC007115, AF138304, AL517167, AW444736, BM672011, BX094949, BX571756, DA424244

Consensus CDS

CCDS44951.1

UniProtKB/TrEMBL

A0A7I2PRI8

Related

ENSP00000398514.2, ENST00000456569.2

Conserved Domains (1) summary

cl02423
Location:54 → 71

LRRNT; Leucine rich repeat N-terminal domain