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    Il10ra interleukin 10 receptor, alpha [ Mus musculus (house mouse) ]

    Gene ID: 16154, updated on 2-Nov-2024

    Summary

    Official Symbol
    Il10raprovided by MGI
    Official Full Name
    interleukin 10 receptor, alphaprovided by MGI
    Primary source
    MGI:MGI:96538
    See related
    Ensembl:ENSMUSG00000032089 AllianceGenome:MGI:96538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il10r; CDw210; CDw210a; IL-10R1; IL-10RA; mIL-10R
    Summary
    Predicted to enable interleukin-10 binding activity and interleukin-10 receptor activity. Predicted to be involved in several processes, including interleukin-10-mediated signaling pathway; intestinal epithelial structure maintenance; and ubiquitin-dependent endocytosis. Predicted to be located in cytosol. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease 28. Orthologous to human IL10RA (interleukin 10 receptor subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 30.8), thymus adult (RPKM 10.6) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Il10ra in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45165135..45180447, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45253837..45269149, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39327 Neighboring gene transmembrane protease, serine 4 Neighboring gene predicted gene, 57797 Neighboring gene small integral membrane protein 35 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45029701-45030002 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45054121-45054422 Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene transmembrane protease, serine 13 Neighboring gene STARR-seq mESC enhancer starr_23995 Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene predicted gene, 57798

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables interleukin-10 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-10 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-10 receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-10 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in interleukin-10-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-10-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intestinal epithelial structure maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intestinal epithelial structure maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    interleukin-10 receptor subunit alpha
    Names
    IL-10 receptor subunit alpha
    IL-10R subunit 1
    IL-10R subunit alpha
    interleukin-10 receptor subunit 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324486.1NP_001311415.1  interleukin-10 receptor subunit alpha isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice donor site in the 5' coding region, compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK149680, AK149899, AK153120, BY691362
      Consensus CDS
      CCDS85671.1
      UniProtKB/TrEMBL
      H3BKN6, Q3UE89
      Related
      ENSMUSP00000135461.2, ENSMUST00000176222.2
    2. NM_008348.3NP_032374.1  interleukin-10 receptor subunit alpha isoform 1 precursor

      See identical proteins and their annotated locations for NP_032374.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK149899, AK159566, BY691362
      Consensus CDS
      CCDS23131.1
      UniProtKB/Swiss-Prot
      Q61727
      UniProtKB/TrEMBL
      Q3U6I9, Q3UDL4
      Related
      ENSMUSP00000034594.10, ENSMUST00000034594.16
      Conserved Domains (2) summary
      pfam01108
      Location:21114
      Tissue_fac; Tissue factor
      cl21522
      Location:132229
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_136903.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate 5' internal exon, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This transcript is potentially protein coding if an alternate upstream translational start codon is used.
      Source sequence(s)
      AK149899, AK153120, BY691362
      Related
      ENSMUST00000176808.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45165135..45180447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)