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    Igfbp2 insulin-like growth factor binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 16008, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Igfbp2provided by MGI
    Official Full Name
    insulin-like growth factor binding protein 2provided by MGI
    Primary source
    MGI:MGI:96437
    See related
    Ensembl:ENSMUSG00000039323 AllianceGenome:MGI:96437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IBP-2; Igfbp-2; mIGFBP-2
    Summary
    The protein encoded by this gene is one of several similar proteins that bind insulin-like growth factors I and II (Igf-I and Igf-II). The encoded protein can be secreted into the bloodstream, where it binds Igf-I and Igf-II with high affinity, or it can remain intracellular, interacting with many different ligands. Two transcript variants, one encoding a secreted isoform and the other encoding a nonsecreted isoform, have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in bladder adult (RPKM 311.4), liver E18 (RPKM 285.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Igfbp2 in Genome Data Viewer
    Location:
    1 C3; 1 36.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (72863650..72891633)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (72824480..72852474)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51632 Neighboring gene predicted gene, 39663 Neighboring gene predicted gene, 30788 Neighboring gene predicted gene, 30847 Neighboring gene STARR-seq mESC enhancer starr_01288 Neighboring gene STARR-seq mESC enhancer starr_01290 Neighboring gene insulin-like growth factor binding protein 5 Neighboring gene STARR-seq mESC enhancer starr_01295 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased fat mass, decreased myofiber size, and a shift to glycolytic muscle metabolism in adolescent male transgenic mice overexpressing IGFBP-2. Rehfeldt C, et al. Am J Physiol Endocrinol Metab, 2010 Aug. PMID 20501873
    2. Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice. Hoeflich A, et al. Aging Cell, 2016 Feb. PMID 26507795, Free PMC Article
    3. Igfbp2 Deletion in Ovariectomized Mice Enhances Energy Expenditure but Accelerates Bone Loss. DeMambro VE, et al. Endocrinology, 2015 Nov. PMID 26230658, Free PMC Article
    4. The RGD sequence present in IGFBP-2 is required for reduced glucose clearance after oral glucose administration in female transgenic mice. Reyer A, et al. Am J Physiol Endocrinol Metab, 2015 Aug 15. PMID 26105006
    5. Glioma progression is mediated by an addiction to aberrant IGFBP2 expression and can be blocked using anti-IGFBP2 strategies. Phillips LM, et al. J Pathol, 2016 Jul. PMID 27125842, Free PMC Article

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2.
      Title: A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2.
    2. Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2.
      Title: Disease-relevant upregulation of P2Y(1) receptor in astrocytes enhances neuronal excitability via IGFBP2.
    3. IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin alpha5/FAK in diabetic kidney disease.
      Title: IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage via integrin α5/FAK in diabetic kidney disease.
    4. The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
      Title: The role of HMGA2 in activating the IGFBP2 expression to promote angiogenesis and LUAD metastasis via the PI3K/AKT/VEGFA signaling pathway.
    5. Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
      Title: Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.
    6. FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
      Title: FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation.
    7. Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy.
      Title: Insulin-like growth factor binding protein 2 null mice (Igfbp2-/-) are protected against trabecular bone loss after vertical sleeve gastrectomy.
    8. Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
      Title: Serum insulin-like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma-associated malnutrition and muscle wasting.
    9. Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
      Title: Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice.
    10. Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.
      Title: Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables insulin-like growth factor I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin-like growth factor I binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables insulin-like growth factor II binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin-like growth factor II binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables insulin-like growth factor II binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor ligand inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of activated T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of insulin-like growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    insulin-like growth factor-binding protein 2
    Names
    IGF-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310659.2 → NP_001297588.1  insulin-like growth factor-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115870, AC121498
      Consensus CDS
      CCDS78613.1
      UniProtKB/TrEMBL
      D3YU40
      Conserved Domains (1) summary
      pfam00086
      Location:60 → 139
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    2. NM_001420245.1 → NP_001407174.1  insulin-like growth factor-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115870, AC121498
      UniProtKB/TrEMBL
      D3YU40

    3. NM_008342.4 → NP_032368.2  insulin-like growth factor-binding protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032368.2

      Status: VALIDATED

      Source sequence(s)
      AC115870, AC121498
      Consensus CDS
      CCDS15036.1
      UniProtKB/Swiss-Prot
      P47877, Q61722, Q91VK7
      UniProtKB/TrEMBL
      Q9D057
      Related
      ENSMUSP00000046610.5, ENSMUST00000047328.11
      Conserved Domains (2) summary
      smart00121
      Location:38 → 116
      IB; Insulin growth factor-binding protein homologues
      pfam00086
      Location:207 → 286
      Thyroglobulin_1; Thyroglobulin type-1 repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      72863650..72891633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250357.2 → XP_030106217.1  insulin-like growth factor-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      D3YU40
      Related
      ENSMUSP00000112706.2, ENSMUST00000120564.2
      Conserved Domains (1) summary
      pfam00086
      Location:60 → 139
      Thyroglobulin_1; Thyroglobulin type-1 repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47877.2 GenPept UniProtKB/Swiss-Prot:P47877

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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