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    Lcp2 lymphocyte cytosolic protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 155918, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Lcp2provided by RGD
    Official Full Name
    lymphocyte cytosolic protein 2provided by RGD
    Primary source
    RGD:619743
    See related
    EnsemblRapid:ENSRNOG00000005620 AllianceGenome:RGD:619743
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Slp76
    Summary
    Predicted to be involved in cell surface receptor signaling pathway; intracellular signal transduction; and positive regulation of protein kinase activity. Predicted to act upstream of or within mast cell activation. Predicted to be located in cell-cell junction; cytosol; and plasma membrane raft. Predicted to be part of TCR signalosome. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCP2 (lymphocyte cytosolic protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 212.4), Spleen (RPKM 146.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lcp2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (19146846..19193750)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (18642600..18689562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18996523..19043289)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel interacting protein 1 Neighboring gene uncharacterized LOC120095245 Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 1 Neighboring gene uncharacterized LOC134480773 Neighboring gene similar to human chromosome 5 open reading frame 58 Neighboring gene forkhead box I1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. Devkota S, et al. J Mol Biol, 2015 Aug 28. PMID 25916191, Free PMC Article
    2. Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. Wu JN, et al. J Immunol, 2004 Jun 1. PMID 15153494
    3. SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. Hendricks-Taylor LR, et al. J Biol Chem, 1997 Jan 10. PMID 8995445
    4. Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. Lasserre R, et al. EMBO J, 2010 Jul 21. PMID 20551903, Free PMC Article
    5. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. Roose JP, et al. PLoS Biol, 2003 Nov. PMID 14624253, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLCgamma1 can be primed for ITK-mediated phosphorylation on Y783 by a specific region of the adaptor protein, SLP-76.
      Title: Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TCR signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte cytosolic protein 2
    Names
    lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130421.2 → NP_569105.1  lymphocyte cytosolic protein 2

      See identical proteins and their annotated locations for NP_569105.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100066
      UniProtKB/TrEMBL
      A0A8J8YIH6, F1LNJ9, Q920L0
      Related
      ENSRNOP00000098753.1, ENSRNOT00000168848.1
      Conserved Domains (3) summary
      cd09522
      Location:10 → 78
      SAM_SLP76; SAM domain of SLP76 subfamily
      smart00454
      Location:12 → 70
      SAM; Sterile alpha motif
      cd09929
      Location:402 → 523
      SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      19146846..19193750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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