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    Gss glutathione synthetase [ Mus musculus (house mouse) ]

    Gene ID: 14854, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Gssprovided by MGI
    Official Full Name
    glutathione synthetaseprovided by MGI
    Primary source
    MGI:MGI:95852
    See related
    Ensembl:ENSMUSG00000027610 AllianceGenome:MGI:95852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GSH-S; GS-A/GS-B
    Summary
    Enables glutathione synthase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; glutathione synthetase deficiency of erythrocytes; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 72.6), colon adult (RPKM 41.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gss in Genome Data Viewer
    Location:
    2 H1; 2 77.26 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155405101..155434730, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155563181..155592810, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 7 Neighboring gene STARR-positive B cell enhancer ABC_E1258 Neighboring gene acyl-CoA synthetase short-chain family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E7875 Neighboring gene acyl-CoA synthetase short-chain family member 2, opposite strand Neighboring gene glutathione synthase, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_06145 Neighboring gene STARR-positive B cell enhancer ABC_E6005 Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice. Zhu H, et al. Cell Death Dis, 2023 Dec 19. PMID 38114454, Free PMC Article
    2. Induction of glutathione synthetase by 1,10-phenanthroline. Sun Y. FEBS Lett, 1997 May 12. PMID 9180259
    3. Developmental patterns of zygotes from transgenic female mice with elevated tissue glutathione. Rzucidlo SJ, et al. J Exp Zool, 2000 Feb 1. PMID 10617859
    4. Glutathione is essential for early embryogenesis--analysis of a glutathione synthetase knockout mouse. Winkler A, et al. Biochem Biophys Res Commun, 2011 Aug 19. PMID 21802407
    5. A single mouse glutathione synthetase gene encodes six mRNAs with different 5' ends. Shi ZZ, et al. Arch Biochem Biophys, 1996 Jul 15. PMID 8660701

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice.
      Title: Gss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice.
    2. Cystine/Glutamate Xc[-] Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
      Title: Cystine/Glutamate Xc(-) Antiporter Induction Compensates for Transsulfuration Pathway Repression by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to Ensure Cysteine for Hepatic Glutathione Biosynthesis.
    3. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase
      Title: A futile cycle, formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase: the cause of cellular ATP depletion in nephrotic cystinosis?
    4. Hypoxia decreased 2 key enzyme activities that regulate GSH synthesis, glutamate cysteine ligase (GCL) (E.C. 6.3.2.2) and glutathione synthase (GS) (E.C. 6.3.2.3)
      Title: Hypoxia and kinase activity regulate lung epithelial cell glutathione.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutathione synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutathione synthetase
    Names
    GSH synthetase
    glutathione synthase
    NP_001278040.1
    NP_032206.1
    XP_006498844.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291111.1 → NP_001278040.1  glutathione synthetase isoform b

      See identical proteins and their annotated locations for NP_001278040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AI846976, AK149577, AL844852
      Consensus CDS
      CCDS71167.1
      UniProtKB/TrEMBL
      Q3UEE2, Q8R436
      Related
      ENSMUSP00000135319.2, ENSMUST00000130881.8
      Conserved Domains (1) summary
      cl00170
      Location:1 → 405
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    2. NM_008180.2 → NP_032206.1  glutathione synthetase isoform a

      See identical proteins and their annotated locations for NP_032206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI846976, AK169096, AL844852
      Consensus CDS
      CCDS16951.1
      UniProtKB/Swiss-Prot
      P51855
      UniProtKB/TrEMBL
      Q3TWM2, Q541E2
      Related
      ENSMUSP00000078630.7, ENSMUST00000079691.13
      Conserved Domains (1) summary
      cd00228
      Location:6 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      155405101..155434730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498781.4 → XP_006498844.1  glutathione synthetase isoform X1

      See identical proteins and their annotated locations for XP_006498844.1

      UniProtKB/Swiss-Prot
      P51855
      UniProtKB/TrEMBL
      Q3TWM2, Q541E2
      Conserved Domains (1) summary
      cd00228
      Location:6 → 474
      eu-GS; Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51855.1 GenPept UniProtKB/Swiss-Prot:P51855

    Gene LinkOut

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