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    CTAG1B cancer/testis antigen 1B [ Homo sapiens (human) ]

    Gene ID: 1485, updated on 27-Aug-2024

    Summary

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    Official Symbol
    CTAG1Bprovided by HGNC
    Official Full Name
    cancer/testis antigen 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:2491
    See related
    Ensembl:ENSG00000184033 MIM:300156; AllianceGenome:HGNC:2491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTAG; ESO1; CT6.1; CTAG1; LAGE-2; LAGE2B; NY-ESO-1
    Summary
    The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]
    Expression
    Restricted expression toward testis (RPKM 4.5) See more
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    Genomic context

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    Location:
    Xq28
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154617609..154619282, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152854032..152855700, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153845865..153847533, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene activating transcription factor 4 pseudogene 2 Neighboring gene cancer/testis antigen 1A Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153825347-153825934 Neighboring gene activating transcription factor 4 pseudogene 1 Neighboring gene family with sequence similarity 223 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells. Gong W, et al. Cells, 2021 Jan 14. PMID 33466646, Free PMC Article
    2. First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1. Somaiah N, et al. Clin Cancer Res, 2019 Oct 1. PMID 31227504
    3. NY-ESO-1- and survivin-specific T-cell responses in the peripheral blood from patients with glioma. Liu Z, et al. Cancer Immunol Immunother, 2018 Feb. PMID 29058035, Free PMC Article
    4. Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status. Shiohama Y, et al. Virol J, 2017 Jul 17. PMID 28716148, Free PMC Article
    5. Expression of NY-ESO-1 in Triple-Negative Breast Cancer Is Associated with Tumor-Infiltrating Lymphocytes and a Good Prognosis. Lee HJ, et al. Oncology, 2015. PMID 26413775

    See all (114) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene of the month: cancer testis antigen gene 1b (NY-ESO-1).
      Title: Gene of the month: cancer testis antigen gene 1b (NY-ESO-1).
    2. The role of PRAME and NY-ESO-1 as potential therapeutic and prognostic biomarkers in triple-negative breast carcinomas.
      Title: The role of PRAME and NY-ESO-1 as potential therapeutic and prognostic biomarkers in triple-negative breast carcinomas.
    3. Clinicopathological assessment of cancer/testis antigens NYESO1 and MAGEA4 in osteosarcoma.
      Title: Clinicopathological assessment of cancer/testis antigens NY‑ESO‑1 and MAGE‑A4 in osteosarcoma.
    4. Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations.
      Title: Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement distinguishes myxoid liposarcoma from its mimics with detection of novel DDIT3 gene copy number variations.
    5. HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome.
      Title: HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome.
    6. Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells.
      Title: Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells.
    7. MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.
      Title: MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.
    8. The programmed cell death protein-1/programmed cell death ligand 1 expression, CD3+ T cell infiltration, NY-ESO-1 expression, and microsatellite instability phenotype in primary cutaneous melanoma and mucosal melanoma and their clinical significance and prognostic value: a study of 89 consecutive cases.
      Title: The programmed cell death protein-1/programmed cell death ligand 1 expression, CD3+ T cell infiltration, NY-ESO-1 expression, and microsatellite instability phenotype in primary cutaneous melanoma and mucosal melanoma and their clinical significance and prognostic value: a study of 89 consecutive cases.
    9. First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1.
      Title: First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1.
    10. High NY-ESO-1 expression is associated with non-small cell lung cancer metastasis.
      Title: Expression of New York esophageal squamous cell carcinoma 1 and its association with Foxp3 and indoleamine-2,3-dioxygenase in microenvironment of nonsmall cell lung cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (94)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    cancer/testis antigen 1
    Names
    New York esophageal squamous cell carcinoma 1
    autoimmunogenic cancer/testis antigen NY-ESO-1
    cancer antigen 3
    cancer/testis antigen 6.1
    l antigen family member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327.3 → NP_001318.1  cancer/testis antigen 1

      See identical proteins and their annotated locations for NP_001318.1

      Status: REVIEWED

      Source sequence(s)
      AC244107, U87459
      Consensus CDS
      CCDS14758.1
      UniProtKB/Swiss-Prot
      A1L417, B7WNL9, P78358, Q7LBY4, Q9NY13
      Related
      ENSP00000332602.2, ENST00000328435.3
      Conserved Domains (1) summary
      pfam09341
      Location:92 → 162
      Pcc1; Transcription factor Pcc1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      154617609..154619282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      152854032..152855700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78358.1 GenPept UniProtKB/Swiss-Prot:P78358

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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