Gk2 glycerol kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gk2provided by MGI
Official Full Name: glycerol kinase 2provided by MGI
Primary source: MGI:MGI:1329027
See related: Ensembl:ENSMUSG00000050553 AllianceGenome:MGI:1329027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GKTA; Gk-rs2
Summary: Predicted to enable glycerol kinase activity. Involved in sperm mitochondrial sheath assembly. Located in mitochondrial outer membrane and sperm mitochondrial sheath. Orthologous to human GK2 (glycerol kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
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Genomic context

Location:: 5 E3; 5 47.71 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (97602989..97604882, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (97455130..97457023, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GK2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.
Title: Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

General gene information

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Markers

mGk2 (e-PCR)
- UniSTS:514578

NoName (e-PCR)
- UniSTS:546792

Gk2 (e-PCR), detects polymorphism
- UniSTS:546792

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables glycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol-3-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sperm mitochondrial sheath assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm mitochondrial sheath	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glycerol kinase 2

Names: ATP:glycerol 3-phosphotransferase 2; GK 2; glucokinase activity, related sequence 2; glycerokinase 2; glycerol kinase, testis specific 2

NP_034424.1

EC 2.7.1.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010294.2 → NP_034424.1 glycerol kinase 2

See identical proteins and their annotated locations for NP_034424.1

Status: VALIDATED

Source sequence(s)

AC122875, BC050764, BC061147

Consensus CDS

CCDS19454.1

UniProtKB/Swiss-Prot

Q9WU65

UniProtKB/TrEMBL

Q8BW08

Related

ENSMUSP00000052226.3, ENSMUST00000059657.4

Conserved Domains (2) summary

cd07792
Location:11 → 513

FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases

TIGR01311
Location:11 → 513

glycerol_kin; glycerol kinase