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    IL17RE interleukin 17 receptor E [ Homo sapiens (human) ]

    Gene ID: 132014, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IL17REprovided by HGNC
    Official Full Name
    interleukin 17 receptor Eprovided by HGNC
    Primary source
    HGNC:HGNC:18439
    See related
    Ensembl:ENSG00000163701 MIM:614995; AllianceGenome:HGNC:18439
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
    Expression
    Broad expression in duodenum (RPKM 10.6), skin (RPKM 9.9) and 17 other tissues See more
    Orthologs
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    Genomic context

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    See IL17RE in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (9902093..9916402)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (9894115..9908425)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9944296..9958086)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cell death inducing DFFA like effector c Neighboring gene Sharpr-MPRA regulatory region 14744 Neighboring gene jagunal homolog 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9944736-9945405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14049 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9958035-9958574 Neighboring gene RNA, U6 small nuclear 882, pseudogene Neighboring gene interleukin 17 receptor C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:9970047-9970546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19413 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:9980935-9981732 Neighboring gene cysteine rich with EGF like domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients. Jiang Y, et al. Clin Exp Immunol, 2022 May 12. PMID 35553626, Free PMC Article
    2. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy. Wang J, et al. Int Immunopharmacol, 2023 Jul. PMID 37235960
    3. Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects. Barati M, et al. J Interferon Cytokine Res, 2020 Mar. PMID 31905037
    4. Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics. Tang W, et al. Int Arch Allergy Immunol, 2016. PMID 27685606
    5. Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus. Pan HF, et al. Mol Biol Rep, 2013 Jan. PMID 23054011

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
      Title: Clinical significance of Interleukin 17 receptor E in diabetic nephropathy.
    2. Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients.
      Title: Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients.
    3. Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects.
      Title: Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects.
    4. IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology.
      Title: IL-17C/IL-17RE: Emergence of a Unique Axis in T(H)17 Biology.
    5. Our findings suggest that the IL-25/IL-25R axis may play an important role in promoting the recruitment and proinflammatory function of eosinophils in allergic asthma.
      Title: Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics.
    6. IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens.
      Title: IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23658, MGC71884

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17 receptor E
    Names
    IL-17 receptor E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193380.2 → NP_001180309.1  interleukin-17 receptor E isoform 6 precursor

      See identical proteins and their annotated locations for NP_001180309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 6, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC018809, AF458069, AK074238, AK096801, AK297697
      Consensus CDS
      CCDS54552.1
      UniProtKB/TrEMBL
      B4DMZ3
      Related
      ENSP00000388086.2, ENST00000454190.6
      Conserved Domains (1) summary
      pfam15037
      Location:75 → 433
      IL17_R_N; Interleukin-17 receptor extracellular region

    2. NM_153480.2 → NP_705613.1  interleukin-17 receptor E isoform 1 precursor

      See identical proteins and their annotated locations for NP_705613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AF458069, AK074238, BC137077
      Consensus CDS
      CCDS2589.1
      UniProtKB/Swiss-Prot
      B2RB34, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8NFR9, Q8TEC2
      UniProtKB/TrEMBL
      J3KQN7
      Related
      ENSP00000373325.3, ENST00000383814.8
      Conserved Domains (2) summary
      pfam15037
      Location:75 → 448
      IL17_R_N; Interleukin-17 receptor extracellular region
      cl23749
      Location:488 → 611
      TIR_2; TIR domain

    3. NM_153481.2 → NP_705614.1  interleukin-17 receptor E isoform 2

      See identical proteins and their annotated locations for NP_705614.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK074238, AK096801, BC137077
      UniProtKB/Swiss-Prot
      Q8NFR9
      Conserved Domains (2) summary
      pfam15037
      Location:1 → 332
      IL17_R_N; Interleukin-17 receptor extracellular region
      cl23749
      Location:372 → 495
      TIR_2; TIR domain

    4. NM_153483.2 → NP_705616.2  interleukin-17 receptor E isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK074238, BC137077, DA592287
      UniProtKB/TrEMBL
      J3KQN7
      Related
      ENSP00000404916.1, ENST00000421412.5
      Conserved Domains (2) summary
      pfam15037
      Location:115 → 488
      IL17_R_N; Interleukin-17 receptor extracellular region
      cl23749
      Location:528 → 651
      TIR_2; TIR domain

    RNA

    1. NR_104198.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF458069, AK096793
      Related
      ENST00000383815.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      9902093..9916402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533361.4 → XP_011531663.2  interleukin-17 receptor E isoform X2

    2. XM_047447458.1 → XP_047303414.1  interleukin-17 receptor E isoform X1

      UniProtKB/Swiss-Prot
      B2RB34, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8NFR9, Q8TEC2

    3. XM_047447460.1 → XP_047303416.1  interleukin-17 receptor E isoform X4

    4. XM_011533362.3 → XP_011531664.1  interleukin-17 receptor E isoform X7

      UniProtKB/TrEMBL
      B4DMZ3
      Conserved Domains (1) summary
      pfam15037
      Location:75 → 366
      IL17_R_N; Interleukin-17 receptor extracellular region

    5. XM_024453350.2 → XP_024309118.1  interleukin-17 receptor E isoform X5

      UniProtKB/TrEMBL
      B4DMZ3
      Conserved Domains (1) summary
      pfam15037
      Location:79 → 432
      IL17_R_N; Interleukin-17 receptor extracellular region

    6. XM_047447462.1 → XP_047303418.1  interleukin-17 receptor E isoform X8

    7. XM_011533364.3 → XP_011531666.1  interleukin-17 receptor E isoform X10

      Conserved Domains (1) summary
      pfam15037
      Location:75 → 366
      IL17_R_N; Interleukin-17 receptor extracellular region

    8. XM_011533363.3 → XP_011531665.1  interleukin-17 receptor E isoform X9

      Conserved Domains (1) summary
      pfam15037
      Location:75 → 409
      IL17_R_N; Interleukin-17 receptor extracellular region

    9. XM_047447459.1 → XP_047303415.1  interleukin-17 receptor E isoform X3

    10. XM_006712976.2 → XP_006713039.1  interleukin-17 receptor E isoform X6

      See identical proteins and their annotated locations for XP_006713039.1

      UniProtKB/Swiss-Prot
      Q8NFR9
      Conserved Domains (2) summary
      pfam15037
      Location:1 → 332
      IL17_R_N; Interleukin-17 receptor extracellular region
      cl23749
      Location:372 → 495
      TIR_2; TIR domain

    11. XM_047447464.1 → XP_047303420.1  interleukin-17 receptor E isoform X12

    12. XM_047447463.1 → XP_047303419.1  interleukin-17 receptor E isoform X11

    RNA

    1. XR_940382.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      9894115..9908425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345267.1 → XP_054201242.1  interleukin-17 receptor E isoform X2

    2. XM_054345266.1 → XP_054201241.1  interleukin-17 receptor E isoform X1

      UniProtKB/Swiss-Prot
      B2RB34, B2RNR1, B9EH65, Q6P532, Q8N8H7, Q8N8H8, Q8NFR9, Q8TEC2

    3. XM_054345269.1 → XP_054201244.1  interleukin-17 receptor E isoform X4

    4. XM_054345270.1 → XP_054201245.1  interleukin-17 receptor E isoform X5

    5. XM_054345272.1 → XP_054201247.1  interleukin-17 receptor E isoform X7

    6. XM_054345273.1 → XP_054201248.1  interleukin-17 receptor E isoform X8

    7. XM_054345275.1 → XP_054201250.1  interleukin-17 receptor E isoform X10

    8. XM_054345274.1 → XP_054201249.1  interleukin-17 receptor E isoform X9

    9. XM_054345268.1 → XP_054201243.1  interleukin-17 receptor E isoform X3

    10. XM_054345271.1 → XP_054201246.1  interleukin-17 receptor E isoform X6

    11. XM_054345277.1 → XP_054201252.1  interleukin-17 receptor E isoform X12

    12. XM_054345276.1 → XP_054201251.1  interleukin-17 receptor E isoform X11

    RNA

    1. XR_008486659.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144640.2: Suppressed sequence

      Description
      NM_144640.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NFR9.1 GenPept UniProtKB/Swiss-Prot:Q8NFR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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