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    JDP2 Jun dimerization protein 2 [ Homo sapiens (human) ]

    Gene ID: 122953, updated on 2-Nov-2024

    Summary

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    Official Symbol
    JDP2provided by HGNC
    Official Full Name
    Jun dimerization protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17546
    See related
    Ensembl:ENSG00000140044 MIM:608657; AllianceGenome:HGNC:17546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JUNDM2
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 5.0), bone marrow (RPKM 4.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See JDP2 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (75426943..75474107)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (69637134..69683532)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (75894427..75940810)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5944 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36717 Neighboring gene long intergenic non-protein coding RNA 1220 Neighboring gene developmental pluripotency associated 5 pseudogene 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_36725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75800727-75801226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:75894221-75894778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5947 Neighboring gene JDP2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75904146-75904649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75905657-75906159 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75907363-75908346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75918700-75919214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919215-75919730 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75919731-75920244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75925593-75926141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75941017-75941518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:75946817-75947707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:75980965-75981530 Neighboring gene uncharacterized LOC105370572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8753 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:76004983-76005197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8756 Neighboring gene basic leucine zipper ATF-like transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells. Calicchio R, et al. Am J Pathol, 2013 Dec. PMID 24120378
    2. Involvement of Jun dimerization protein 2 (JDP2) in the maintenance of Epstein-Barr virus latency. Murata T, et al. J Biol Chem, 2011 Jun 24. PMID 21525011, Free PMC Article
    3. Histone chaperone Jun dimerization protein 2 (JDP2): role in cellular senescence and aging. Huang YC, et al. Kaohsiung J Med Sci, 2010 Oct. PMID 20950777
    4. The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma patients. Chen YL, et al. Hum Pathol, 2017 May. PMID 28315425
    5. Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis. Lerdrup M, et al. Biochim Biophys Acta, 2005 Aug 15. PMID 16026868

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Palmitic acid-induced microRNA-143-5p expression promotes the epithelial-mesenchymal transition of retinal pigment epithelium via negatively regulating JDP2.
      Title: Palmitic acid-induced microRNA-143-5p expression promotes the epithelial-mesenchymal transition of retinal pigment epithelium via negatively regulating JDP2.
    2. JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis.
      Title: JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis.
    3. Down-regulated lncRNA AGAP2-AS1 contributes to pre-eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype.
      Title: Down-regulated lncRNA AGAP2-AS1 contributes to pre-eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype.
    4. JDP2 is downregulated in HCC tissues and cells, and overexpressed JDP2 facilitated HCC cell invasion and EMT.
      Title: miR-501 acts as an independent prognostic factor that promotes the epithelial-mesenchymal transition through targeting JDP2 in hepatocellular carcinoma.
    5. These studies establish JDP2 as a novel oncogene in high-risk T cell acute lymphoblastic leukemia.
      Title: JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
    6. JDP2 was downregulated in myelodysplastic syndrome. Its expression was inversely related to disease aggressiveness and AML transformation. JDP2 suppression is a direct result of reduced PU.1. PU.1 and JDP2 expression correlate and are concurrently reduced with the extent of differentiation arrest and aggression/prognosis in MDS/AML. It was upregulated upon azacytidine treatment.
      Title: Using PU.1 and Jun dimerization protein 2 transcription factor expression in myelodysplastic syndromes to predict treatment response and leukaemia transformation.
    7. In hepatocellular carcinoma, high expression of JDP2 is significantly correlated with smaller tumor size, early stage HCC and better survival.
      Title: The expression of a tumor suppressor gene JDP2 and its prognostic value in hepatocellular carcinoma patients.
    8. Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.
      Title: Preeclamptic plasma induces transcription modifications involving the AP-1 transcriptional regulator JDP2 in endothelial cells.
    9. Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
      Title: Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.
    10. the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism.
      Title: The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of periodontal pathogen colonization.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP response element binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leucine zipper domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jun dimerization protein 2
    Names
    progesterone receptor co-activator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135047.2 → NP_001128519.1  jun dimerization protein 2 isoform a

      See identical proteins and their annotated locations for NP_001128519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC009363, AF111167, AI916777, BC051303, BU740697
      Consensus CDS
      CCDS9842.1
      UniProtKB/Swiss-Prot
      J3KN58, O95430, Q8WYK2, Q9UIE4
      UniProtKB/TrEMBL
      H0YKE4
      Related
      ENSP00000415558.2, ENST00000419727.6
      Conserved Domains (2) summary
      cd14686
      Location:82 → 126
      bZIP; coiled coil [structural motif]
      cl21462
      Location:82 → 135
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. NM_001135048.2 → NP_001128520.1  jun dimerization protein 2 isoform a

      See identical proteins and their annotated locations for NP_001128520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (a).
      Source sequence(s)
      AC009363, AF111167, BC051303, BE389064, BU740697
      Consensus CDS
      CCDS9842.1
      UniProtKB/Swiss-Prot
      J3KN58, O95430, Q8WYK2, Q9UIE4
      UniProtKB/TrEMBL
      H0YKE4
      Related
      ENSP00000498745.1, ENST00000651602.1
      Conserved Domains (2) summary
      cd14686
      Location:82 → 126
      bZIP; coiled coil [structural motif]
      cl21462
      Location:82 → 135
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    3. NM_001135049.1 → NP_001128521.1  jun dimerization protein 2 isoform b

      See identical proteins and their annotated locations for NP_001128521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) is longer at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC009363, BC051303, BU740697
      Consensus CDS
      CCDS45139.1
      UniProtKB/Swiss-Prot
      Q8WYK2
      Related
      ENSP00000267569.5, ENST00000267569.5
      Conserved Domains (1) summary
      cd14722
      Location:93 → 146
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

    4. NM_130469.3 → NP_569736.1  jun dimerization protein 2 isoform a

      See identical proteins and their annotated locations for NP_569736.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longest transcript and encodes the shorter isoform (a). Variants 1, 2 and 3 encode the same isoform.
      Source sequence(s)
      AC009363, BC051303, BC068196, BU740697
      Consensus CDS
      CCDS9842.1
      UniProtKB/Swiss-Prot
      J3KN58, O95430, Q8WYK2, Q9UIE4
      UniProtKB/TrEMBL
      H0YKE4
      Related
      ENSP00000399587.2, ENST00000435893.6
      Conserved Domains (2) summary
      cd14686
      Location:82 → 126
      bZIP; coiled coil [structural motif]
      cl21462
      Location:82 → 135
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      75426943..75474107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020973.2 → XP_016876462.1  jun dimerization protein 2 isoform X3

      UniProtKB/Swiss-Prot
      J3KN58, O95430, Q8WYK2, Q9UIE4
      UniProtKB/TrEMBL
      H0YKE4
      Conserved Domains (2) summary
      cd14686
      Location:82 → 126
      bZIP; coiled coil [structural motif]
      cl21462
      Location:82 → 135
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. XM_047430942.1 → XP_047286898.1  jun dimerization protein 2 isoform X1

    3. XM_047430944.1 → XP_047286900.1  jun dimerization protein 2 isoform X2

    4. XM_047430943.1 → XP_047286899.1  jun dimerization protein 2 isoform X2

    5. XM_005267332.5 → XP_005267389.1  jun dimerization protein 2 isoform X3

      See identical proteins and their annotated locations for XP_005267389.1

      UniProtKB/Swiss-Prot
      J3KN58, O95430, Q8WYK2, Q9UIE4
      UniProtKB/TrEMBL
      H0YKE4
      Conserved Domains (2) summary
      cd14686
      Location:82 → 126
      bZIP; coiled coil [structural motif]
      cl21462
      Location:82 → 135
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      69637134..69683532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375399.1 → XP_054231374.1  jun dimerization protein 2 isoform X1

    2. XM_054375401.1 → XP_054231376.1  jun dimerization protein 2 isoform X2

    3. XM_054375400.1 → XP_054231375.1  jun dimerization protein 2 isoform X2

    4. XM_054375402.1 → XP_054231377.1  jun dimerization protein 2 isoform X3

      UniProtKB/Swiss-Prot
      J3KN58, O95430, Q8WYK2, Q9UIE4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WYK2.1 GenPept UniProtKB/Swiss-Prot:Q8WYK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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