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    LYZL2 lysozyme like 2 [ Homo sapiens (human) ]

    Gene ID: 119180, updated on 2-Nov-2024

    Summary

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    Official Symbol
    LYZL2provided by HGNC
    Official Full Name
    lysozyme like 2provided by HGNC
    Primary source
    HGNC:HGNC:29613
    See related
    Ensembl:ENSG00000151033 MIM:612748; AllianceGenome:HGNC:29613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYZD2
    Summary
    Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
    Expression
    Restricted expression toward testis (RPKM 14.7) See more
    Orthologs
    all
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    Genomic context

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    See LYZL2 in Genome Data Viewer
    Location:
    10p11.23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (30606221..30629753, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (30637235..30660773, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (30900708..30918682, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:30847997-30848576 Neighboring gene RNA, 7SL, cytoplasmic 63, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr10:30862856-30863438 Neighboring gene uncharacterized LOC105376479 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:30885919-30886534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:30886535-30887149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:30894172-30894987 Neighboring gene uncharacterized LOC124902404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:30932862-30933433 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:30950154-30951353 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:30970851-30972050 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:30972911-30973410 Neighboring gene NANOG hESC enhancer GRCh37_chr10:30976431-30976969 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:30984558-30985757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3221 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3223 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:30994171-30994694 Neighboring gene supervillin family member 2, pseudogene Neighboring gene long intergenic non-protein coding RNA 2644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family. Zhang K, et al. Biol Reprod, 2005 Nov. PMID 16014814
    2. KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise. Argyropoulos G, et al. Physiol Genomics, 2009 Jan 8. PMID 18984674, Free PMC Article
    3. GWAS of dental caries patterns in the permanent dentition. Shaffer JR, et al. J Dent Res, 2013 Jan. PMID 23064961, Free PMC Article
    4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    GWAS of dental caries patterns in the permanent dentition.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lysozyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysozyme-like protein 2
    Names
    lysozyme D2
    lysozyme-2
    NP_898881.3
    XP_011517608.1
    XP_011517609.1
    XP_054220717.1
    XP_054220718.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183058.3 → NP_898881.3  lysozyme-like protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AF139543, AI637906, AL451107, BC066294
      Consensus CDS
      CCDS7167.3
      UniProtKB/Swiss-Prot
      Q6NZ69, Q7Z4W2
      Related
      ENSP00000497408.1, ENST00000647634.2
      Conserved Domains (1) summary
      cd00119
      Location:20 → 143
      LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      30606221..30629753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519306.3 → XP_011517608.1  lysozyme-like protein 2 isoform X1

      Related
      ENSP00000364467.2, ENST00000375318.4
      Conserved Domains (1) summary
      cl00222
      Location:66 → 145
      lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...

    2. XM_011519307.3 → XP_011517609.1  lysozyme-like protein 2 isoform X2

      Conserved Domains (1) summary
      cl00222
      Location:66 → 146
      lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...

    RNA

    1. XR_930469.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      30637235..30660773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364742.1 → XP_054220717.1  lysozyme-like protein 2 isoform X1

    2. XM_054364743.1 → XP_054220718.1  lysozyme-like protein 2 isoform X2

    RNA

    1. XR_008488166.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001031736.1: Suppressed sequence

      Description
      NM_001031736.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z4W2.2 GenPept UniProtKB/Swiss-Prot:Q7Z4W2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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