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    Ap1m2 adaptor protein complex AP-1, mu 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11768, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ap1m2provided by MGI
    Official Full Name
    adaptor protein complex AP-1, mu 2 subunitprovided by MGI
    Primary source
    MGI:MGI:1336974
    See related
    Ensembl:ENSMUSG00000003309 AllianceGenome:MGI:1336974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mu1B; [m]1B; D9Ertd818e
    Summary
    Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 27.8), colon adult (RPKM 22.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ap1m2 in Genome Data Viewer
    Location:
    9 A3; 9 7.76 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21206753..21223617, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21294615..21312349, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene autophagy related 4D, cysteine peptidase Neighboring gene KRI1 homolog Neighboring gene cyclin dependent kinase inhibitor 2D Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21125421-21125608 Neighboring gene predicted gene, 39302 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21132507-21132711 Neighboring gene solute carrier family 44, member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:21136702-21136885 Neighboring gene predicted gene, 36198 Neighboring gene interleukin enhancer binding factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice. Kinashi Y, et al. EBioMedicine, 2024 Aug. PMID 39059316, Free PMC Article
    2. Association of colitis with gut-microbiota dysbiosis in clathrin adapter AP-1B knockout mice. Jangid A, et al. PLoS One, 2020. PMID 32208434, Free PMC Article
    3. Intracellular localization of the M1 muscarinic acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal tryptophan-based motif. Uwada J, et al. J Cell Sci, 2014 Jul 15. PMID 24829147
    4. AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice. Hase K, et al. Gastroenterology, 2013 Sep. PMID 23684748
    5. AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine. Matsumoto R, et al. Cell Mol Life Sci, 2024 Oct 5. PMID 39369131, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine.
      Title: AP-1B regulates interactions of epithelial cells and intraepithelial lymphocytes in the intestine.
    2. Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice.
      Title: Intestinal epithelium dysfunctions cause IgA deposition in the kidney glomeruli of intestine-specific Ap1m2-deficient mice.
    3. AP-1B is required for protein sorting and polarization of intestinal cells in mice. Loss of AP-1B in the intestinal epithelia results in mislocalization of E-cadherin, activation of beta-catenin/Tcf4 complex, proliferation, and hyperplasia.
      Title: AP-1B-mediated protein sorting regulates polarity and proliferation of intestinal epithelial cells in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in basolateral protein secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in trans-Golgi network membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-1 complex subunit mu-2
    Names
    AP-mu chain family member mu1B
    adaptor protein complex AP-1 subunit mu-2
    adaptor-related protein complex 1 mu-2 subunit
    adaptor-related protein complex 1 subunit mu-2
    adaptor-related protein complex AP-1, mu 2 subunit
    clathrin assembly protein complex 1 medium chain 2
    clathrin assembly protein complex 1 mu-2 medium chain 2
    golgi adaptor HA1/AP1 adaptin mu-2 subunit
    mu-adaptin 2
    mu1B-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110300.2 → NP_001103770.1  AP-1 complex subunit mu-2 isoform 1

      See identical proteins and their annotated locations for NP_001103770.1

      Status: VALIDATED

      Source sequence(s)
      AC122525
      Consensus CDS
      CCDS52734.1
      UniProtKB/Swiss-Prot
      Q99LA4, Q9CWP7, Q9WVP1
      UniProtKB/TrEMBL
      A0A0R4J1L4
      Related
      ENSMUSP00000111093.4, ENSMUST00000115433.11
      Conserved Domains (2) summary
      cd14835
      Location:4 → 142
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
      cl10970
      Location:154 → 423
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    2. NM_001410422.1 → NP_001397351.1  AP-1 complex subunit mu-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122525

    3. NM_001410423.1 → NP_001397352.1  AP-1 complex subunit mu-2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122525

    4. NM_009678.3 → NP_033808.2  AP-1 complex subunit mu-2 isoform 2

      See identical proteins and their annotated locations for NP_033808.2

      Status: VALIDATED

      Source sequence(s)
      AC122525
      Consensus CDS
      CCDS22902.1
      UniProtKB/Swiss-Prot
      Q99LA4, Q9CWP7, Q9WVP1
      UniProtKB/TrEMBL
      A0A0R4IZX6
      Related
      ENSMUSP00000003397.8, ENSMUST00000003397.9
      Conserved Domains (2) summary
      cd14835
      Location:4 → 142
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
      cl10970
      Location:154 → 421
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21206753..21223617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVP1.3 GenPept UniProtKB/Swiss-Prot:Q9WVP1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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