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    Oxr1 oxidation resistance 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117520, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Oxr1provided by RGD
    Official Full Name
    oxidation resistance 1provided by RGD
    Primary source
    RGD:621857
    See related
    EnsemblRapid:ENSRNOG00000056487 AllianceGenome:RGD:621857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in response to oxidative stress. Predicted to act upstream of or within several processes, including adult walking behavior; negative regulation of cellular response to oxidative stress; and negative regulation of peptidyl-cysteine S-nitrosylation. Predicted to be located in nucleolus. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in cerebellar hyplasia/atrophy, epilepsy, and global developmental delay. Orthologous to human OXR1 (oxidation resistance 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 675.8), Brain (RPKM 506.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Oxr1 in Genome Data Viewer
    Location:
    7q31
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (74413609..74850487)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (72528750..72965666)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (80351774..80788094)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093645 Neighboring gene uncharacterized LOC102556196 Neighboring gene ribosomal protein L31, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120093810 Neighboring gene small nucleolar RNA, H/ACA box 4 Neighboring gene actin-binding Rho activating protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin. Dianat M, et al. Life Sci, 2020 Sep 1. PMID 32585243
    2. Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence. Rezaei Z, et al. Neurosci Lett, 2020 Apr 17. PMID 32114118
    3. Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas. García-Brito S, et al. Behav Brain Res, 2018 Nov 1. PMID 29953904
    4. MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals. Mo JL, et al. Neurosci Bull, 2019 Oct. PMID 30977043, Free PMC Article
    5. Oxr1 is essential for protection against oxidative stress-induced neurodegeneration. Oliver PL, et al. PLoS Genet, 2011 Oct. PMID 22028674, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence.
      Title: Orexin type-1 receptor inhibition in the rat lateral paragigantocellularis nucleus attenuates development of morphine dependence.
    2. Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin.
      Title: Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin.
    3. MicroRNA-365 up-regulation increases oxidative injury by inhibiting OXR1 expression, while its down-regulation protects neurons from oxidative death by enhancing OXR1-mediated antioxidant signals.
      Title: MicroRNA-365 Knockdown Prevents Ischemic Neuronal Injury by Activating Oxidation Resistance 1-Mediated Antioxidant Signals.
    4. Results showed a deteriorating effect of OXR1 blockade on spatial memory consolidation in the Morris Water Maze, and that increased training is able to counteract such an effect. Additionally, although c-Fos expression cannot be linked to specific neuronal function, the c-Fos data seem to reproduce the behavioural results in a set of regions which have been linked to spatial memory.
      Title: Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93253, MGC114530

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adult walking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-cysteine S-nitrosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxidation resistance protein 1
    Names
    protein C7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197332.2 → NP_001184261.1  oxidation resistance protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001184261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks multiple 5' exons and an internal exon, but has an alternate 5' exon, compared to variant 1. The resulting isoform (3) is much shorter and has a distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HR95
      Conserved Domains (1) summary
      smart00584
      Location:54 → 216
      TLDc; domain in TBC and LysM domain containing proteins

    2. NM_001197907.2 → NP_001184836.1  oxidation resistance protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K7Y2, A0A8I5ZX45
      Related
      ENSRNOP00000074393.1, ENSRNOT00000081948.3
      Conserved Domains (2) summary
      smart00584
      Location:711 → 873
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:100 → 142
      LysM; LysM domain

    3. NM_001414906.1 → NP_001401835.1  oxidation resistance protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    4. NM_057153.5 → NP_476494.3  oxidation resistance protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a few of 5' exons and an internal exon, but has an alternate 5' exon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      B2RYF9, Q4V8B0, Q99MK0
      Related
      ENSRNOP00000070910.2, ENSRNOT00000091355.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      74413609..74850487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594617.3 → XP_017450106.1  oxidation resistance protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYS1
      Related
      ENSRNOP00000095211.2, ENSRNOT00000098283.2

    2. XM_063262910.1 → XP_063118980.1  oxidation resistance protein 1 isoform X4

      Related
      ENSRNOP00000099353.1, ENSRNOT00000155577.1

    3. XM_063262909.1 → XP_063118979.1  oxidation resistance protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7Y2

    4. XM_063262911.1 → XP_063118981.1  oxidation resistance protein 1 isoform X4

      Related
      ENSRNOP00000070768.3, ENSRNOT00000084940.3

    5. XM_039078303.1 → XP_038934231.1  oxidation resistance protein 1 isoform X12

      Conserved Domains (1) summary
      pfam01476
      Location:12 → 54
      LysM; LysM domain

    6. XM_063262913.1 → XP_063118983.1  oxidation resistance protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A1T7

    7. XM_063262912.1 → XP_063118982.1  oxidation resistance protein 1 isoform X8

    8. XM_017594621.2 → XP_017450110.2  oxidation resistance protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y9F4, A0A8I6GLI4
      Conserved Domains (2) summary
      smart00584
      Location:644 → 806
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:33 → 75
      LysM; LysM domain

    9. XM_017594624.3 → XP_017450113.2  oxidation resistance protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZ50
      Related
      ENSRNOP00000075440.2, ENSRNOT00000078354.3
      Conserved Domains (2) summary
      smart00584
      Location:704 → 866
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:93 → 135
      LysM; LysM domain

    10. XM_063262915.1 → XP_063118985.1  oxidation resistance protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A0G2KAL4
      Related
      ENSRNOP00000077275.1, ENSRNOT00000099739.2

    11. XM_039078302.2 → XP_038934230.1  oxidation resistance protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y9F4, A6HR94
      Conserved Domains (2) summary
      smart00584
      Location:623 → 785
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:12 → 54
      LysM; LysM domain

    12. XM_017594623.3 → XP_017450112.1  oxidation resistance protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y9F4

    13. XM_063262914.1 → XP_063118984.1  oxidation resistance protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AHK4

    14. XM_039078301.2 → XP_038934229.1  oxidation resistance protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y9F4, A6HR94
      Conserved Domains (2) summary
      smart00584
      Location:623 → 785
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:12 → 54
      LysM; LysM domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8B0.3 GenPept UniProtKB/Swiss-Prot:Q4V8B0

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