Pabpn1 poly(A) binding protein, nuclear 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pabpn1provided by RGD
Official Full Name: poly(A) binding protein, nuclear 1provided by RGD
Primary source: RGD:619928
See related: EnsemblRapid:ENSRNOG00000042195 AllianceGenome:RGD:619928
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase binding activity and poly(A) binding activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; poly(A)+ mRNA export from nucleus; and positive regulation of polynucleotide adenylyltransferase activity. Located in nuclear inclusion body. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to human PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 80.0), Testes (RPKM 78.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (32337955..32342700)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (28368100..28372712)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33555640..33560251)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.
Title: Novel read-through fusion transcript Bcl2l2-Pabpn1 in glioblastoma cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-57254 (e-PCR)
- UniSTS:39544

MARC_26170-26171:1030649367:1 (e-PCR)
- UniSTS:268968

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase binding	ISO Inferred from Sequence Orthology more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in poly(A)+ mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of polynucleotide adenylyltransferase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nuclear inclusion body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inclusion body	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polyadenylate-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135008.1 → NP_001128480.1 polyadenylate-binding protein 2

See identical proteins and their annotated locations for NP_001128480.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KGX0, G3V7Z8

Related

ENSRNOP00000021096.3, ENSRNOT00000021096.8

Conserved Domains (2) summary

COG0724
Location:109 → 285

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12550
Location:169 → 244

RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins