Wnk1 WNK lysine deficient protein kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wnk1provided by RGD
Official Full Name: WNK lysine deficient protein kinase 1provided by RGD
Primary source: RGD:621141
See related: EnsemblRapid:ENSRNOG00000009956 AllianceGenome:RGD:621141
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsn2; Prkwnk1
Summary: Enables several functions, including ATP binding activity; magnesium ion binding activity; and molecular condensate scaffold activity. Involved in several processes, including cell volume homeostasis; cellular hyperosmotic response; and negative regulation of protein localization to plasma membrane. Located in cytosol and membrane. Is active in GABA-ergic synapse and intracellular non-membrane-bounded organelle. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 878.8), Heart (RPKM 404.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (154800590..154926147, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (153128334..153253905, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (152452211..152578469, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osmosensing by WNK Kinases.
Title: Osmosensing by WNK Kinases.
Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders.
Title: Regulation of CFTR Bicarbonate Channel Activity by WNK1: Implications for Pancreatitis and CFTR-Related Disorders.
A Phosphorylated Intermediate in the Activation of WNK Kinases.
Title: A Phosphorylated Intermediate in the Activation of WNK Kinases.
Suppression of WNK1-SPAK/OSR1 Attenuates Bone Cancer Pain by Regulating NKCC1 and KCC2.
Title: Suppression of WNK1-SPAK/OSR1 Attenuates Bone Cancer Pain by Regulating NKCC1 and KCC2.
these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.
Title: WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
WNK1 interacts with LINGO1 in oligodendrocytes. Knockdown WNK1 attenuated Nogo66-induced inhibition of OPC maturation.
Title: WNK1 is involved in Nogo66 inhibition of OPC differentiation.
The WNK1-AI domain has a circularly permuted topology relative to the OSR1-PF2 domain.
Title: Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain.
Data find that expression of the N termini of all four WNKs results in modest to strong activation of SGK1.
Title: Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.
HSN2 is a nervous system-specific exon of the WNK1 gene (WNK1/HSN2 isoform).
Title: Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.
a novel function of WNK1 in endothelial cells that is critical for angiogenesis and heart development
Title: Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Rat64 (e-PCR)
- UniSTS:118859

RH135198 (e-PCR)
- UniSTS:218475

AU047215 (e-PCR)
- UniSTS:110727

RH143180 (e-PCR)
- UniSTS:232427

RH140646 (e-PCR)
- UniSTS:222715

D8S281 (e-PCR)
- UniSTS:37631

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell volume homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cell volume homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cell volume homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hyperosmotic response	IEA Inferred from Electronic Annotation more info
involved_in cellular hyperosmotic response	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in chemokine (C-C motif) ligand 21 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemokine (C-C motif) ligand 21 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in intracellular chloride ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular chloride ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte migration into lymph node	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte migration into lymph node	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation homeostasis	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of GTPase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell-cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pancreatic juice secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of pancreatic juice secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in non-membrane-bounded organelle assembly	IEA Inferred from Electronic Annotation more info
involved_in non-membrane-bounded organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in non-membrane-bounded organelle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of termination of RNA polymerase II transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of termination of RNA polymerase II transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of termination of RNA polymerase II transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in intracellular non-membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular non-membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase WNK1

Names: protein kinase with no lysine 1

NP_001002823.2

EC 2.7.11.1

NP_001186024.1

EC 2.7.11.1

NP_446246.2

EC 2.7.11.1

XP_008761423.1

EC 2.7.11.1

XP_008761429.1

EC 2.7.11.1

XP_008761434.1

EC 2.7.11.1

XP_038962849.1

EC 2.7.11.1

XP_038962850.1

EC 2.7.11.1

XP_038962852.1

EC 2.7.11.1

XP_038962853.1

EC 2.7.11.1

XP_038962854.1

EC 2.7.11.1

XP_038962855.1

EC 2.7.11.1

XP_038962856.1

EC 2.7.11.1

XP_038962857.1

EC 2.7.11.1

XP_038962858.1

EC 2.7.11.1

XP_038962859.1

EC 2.7.11.1

XP_038962860.1

EC 2.7.11.1

XP_038962861.1

EC 2.7.11.1

XP_038962863.1

EC 2.7.11.1

XP_038962864.1

EC 2.7.11.1

XP_038962865.1

EC 2.7.11.1

XP_038962866.1

EC 2.7.11.1

XP_038962867.1

EC 2.7.11.1

XP_038962868.1

EC 2.7.11.1

XP_038962869.1

EC 2.7.11.1

XP_063141474.1

EC 2.7.11.1

XP_063141475.1

EC 2.7.11.1

XP_063141476.1

EC 2.7.11.1

XP_063141477.1

EC 2.7.11.1

XP_063141478.1

EC 2.7.11.1

XP_063141479.1

EC 2.7.11.1

XP_063141480.1

EC 2.7.11.1

XP_063141481.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002823.2 → NP_001002823.2 serine/threonine-protein kinase WNK1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant inferred from the mouse sequence described in Figure 2F of PubMed ID 18521183.

Source sequence(s)

AF227741, JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I5Y206

Related

ENSRNOP00000013355.5, ENSRNOT00000013355.8

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_001199095.1 → NP_001186024.1 serine/threonine-protein kinase WNK1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the brain and spinal cord variant inferred from the mouse sequence described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 2, which is shorter than isoform 1 but has the same N- and C-termini.

Source sequence(s)

AF227741, JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I5Y206

Related

ENSRNOP00000013622.5, ENSRNOT00000013621.8

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_053794.2 → NP_446246.2 serine/threonine-protein kinase WNK1 isoform 3

See identical proteins and their annotated locations for NP_446246.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AF227741, JAXUCZ010000004

UniProtKB/Swiss-Prot

Q3S2I2, Q6IFS7, Q9JIH7

UniProtKB/TrEMBL

A0A8L2UQL4, A6IL94

Related

ENSRNOP00000072173.2, ENSRNOT00000080788.3

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

154800590..154926147 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285410.1 → XP_063141480.1 serine/threonine-protein kinase WNK1 isoform X29
XM_063285409.1 → XP_063141479.1 serine/threonine-protein kinase WNK1 isoform X28
XM_063285407.1 → XP_063141477.1 serine/threonine-protein kinase WNK1 isoform X23
XM_039106939.2 → XP_038962867.1 serine/threonine-protein kinase WNK1 isoform X19

UniProtKB/TrEMBL

A0A8I6ALH5

Conserved Domains (4) summary

PHA03247
Location:1568 → 1856

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:620 → 1020

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_063285411.1 → XP_063141481.1 serine/threonine-protein kinase WNK1 isoform X30
XM_039106941.2 → XP_038962869.1 serine/threonine-protein kinase WNK1 isoform X27

UniProtKB/TrEMBL

A0A0G2K3A0

Conserved Domains (3) summary

PHA03247
Location:1320 → 1608

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_008763212.4 → XP_008761434.1 serine/threonine-protein kinase WNK1 isoform X26

UniProtKB/TrEMBL

A0A8I5ZQI2, A0A8I6ALH5

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_063285408.1 → XP_063141478.1 serine/threonine-protein kinase WNK1 isoform X24
XM_063285406.1 → XP_063141476.1 serine/threonine-protein kinase WNK1 isoform X22
XM_063285405.1 → XP_063141475.1 serine/threonine-protein kinase WNK1 isoform X21
XM_008763207.4 → XP_008761429.1 serine/threonine-protein kinase WNK1 isoform X20

UniProtKB/TrEMBL

A0A8I6ALH5, A0A8I6AQS9

Related

ENSRNOP00000097067.2, ENSRNOT00000111379.2

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_008763201.4 → XP_008761423.1 serine/threonine-protein kinase WNK1 isoform X18

UniProtKB/TrEMBL

A0A8I6ALH5

Related

ENSRNOP00000080872.2, ENSRNOT00000120316.2

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_039106938.2 → XP_038962866.1 serine/threonine-protein kinase WNK1 isoform X17

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1732 → 2020

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106936.2 → XP_038962864.1 serine/threonine-protein kinase WNK1 isoform X15

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1827 → 2115

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106932.2 → XP_038962860.1 serine/threonine-protein kinase WNK1 isoform X12

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1871 → 2159

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106922.2 → XP_038962850.1 serine/threonine-protein kinase WNK1 isoform X2

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (4) summary

PHA03247
Location:1981 → 2269

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1067 → 1433

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106937.2 → XP_038962865.1 serine/threonine-protein kinase WNK1 isoform X16

UniProtKB/TrEMBL

A0A8I5Y206

Related

ENSRNOP00000072554.2, ENSRNOT00000079513.3

Conserved Domains (3) summary

PHA03247
Location:1733 → 2021

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106935.2 → XP_038962863.1 serine/threonine-protein kinase WNK1 isoform X14

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1828 → 2116

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106931.2 → XP_038962859.1 serine/threonine-protein kinase WNK1 isoform X11

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1872 → 2160

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106928.2 → XP_038962856.1 serine/threonine-protein kinase WNK1 isoform X7

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1067 → 1434

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_063285404.1 → XP_063141474.1 serine/threonine-protein kinase WNK1 isoform X8
XM_039106925.2 → XP_038962853.1 serine/threonine-protein kinase WNK1 isoform X4

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam03154
Location:1067 → 1434

Atrophin-1; Atrophin-1 family

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106927.2 → XP_038962855.1 serine/threonine-protein kinase WNK1 isoform X6

UniProtKB/TrEMBL

A0A8I5Y206

Related

ENSRNOP00000077765.2, ENSRNOT00000113392.2

Conserved Domains (3) summary

PHA03247
Location:1982 → 2270

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106926.2 → XP_038962854.1 serine/threonine-protein kinase WNK1 isoform X5

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1982 → 2270

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106924.2 → XP_038962852.1 serine/threonine-protein kinase WNK1 isoform X3

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1982 → 2270

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106921.2 → XP_038962849.1 serine/threonine-protein kinase WNK1 isoform X1

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1982 → 2270

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106940.2 → XP_038962868.1 serine/threonine-protein kinase WNK1 isoform X25

Conserved Domains (1) summary

PHA03247
Location:1348 → 1636

PHA03247; large tegument protein UL36; Provisional
XM_039106930.2 → XP_038962858.1 serine/threonine-protein kinase WNK1 isoform X10

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1982 → 2270

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106929.2 → XP_038962857.1 serine/threonine-protein kinase WNK1 isoform X9

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1982 → 2270

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
XM_039106933.2 → XP_038962861.1 serine/threonine-protein kinase WNK1 isoform X13

UniProtKB/TrEMBL

A0A8I5Y206

Conserved Domains (3) summary

PHA03247
Location:1982 → 2270

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 563

OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain