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    Slc33a1 solute carrier family 33 (acetyl-CoA transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 11416, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slc33a1provided by MGI
    Official Full Name
    solute carrier family 33 (acetyl-CoA transporter), member 1provided by MGI
    Primary source
    MGI:MGI:1332247
    See related
    Ensembl:ENSMUSG00000027822 AllianceGenome:MGI:1332247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acatn; D630022N01Rik
    Summary
    Predicted to enable acetyl-CoA transmembrane transporter activity and protein homodimerization activity. Predicted to be involved in acetyl-CoA transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including brain; heart; liver; metanephros; and spleen. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 42. Orthologous to human SLC33A1 (solute carrier family 33 member 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 15.9), adrenal adult (RPKM 12.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc33a1 in Genome Data Viewer
    Location:
    3 E1; 3 30.08 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63849744..63872154, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63942323..63964733, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene predicted gene, 34379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:63768480-63768744 Neighboring gene STARR-positive B cell enhancer ABC_E2666 Neighboring gene STARR-seq mESC enhancer starr_07841 Neighboring gene guanine monophosphate synthetase Neighboring gene vomeronasal 2, receptor, pseudogene 3 Neighboring gene vomeronasal 2, receptor 1 Neighboring gene predicted gene, 22165

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis. Cooley MM, et al. Cell Mol Gastroenterol Hepatol, 2021. PMID 33080365, Free PMC Article
    2. Assignment1 of a putative acetyl-CoA transporter gene (Acatn) to mouse chromosome band 3E1-E3 by in situ hybridization. Bora RS, et al. Cytogenet Cell Genet, 1998. PMID 9925934
    3. S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model. Liu P, et al. Dis Model Mech, 2017 Jan 1. PMID 27935820, Free PMC Article
    4. Genomic structure and promoter analysis of putative mouse acetyl-CoA transporter gene. Bora RS, et al. FEBS Lett, 2000 May 12. PMID 10812068
    5. ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1. Sheehan BK, et al. iScience, 2021 Apr 23. PMID 33870132, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis.
      Title: Deficient Endoplasmic Reticulum Acetyl-CoA Import in Pancreatic Acinar Cells Leads to Chronic Pancreatitis.
    2. Results suggest that solute carrier family 33 (acetyl-CoA transporter) member 1 (AT-1) acts as an important metabolic regulator that maintains acetyl-CoA homeostasis by promoting functional crosstalk between different intracellular organelles.
      Title: Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk.
    3. SLC33A1 can negatively regulate BMP signaling in mice.
      Title: S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetyl-CoA transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acetyl-CoA transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acetyl-CoA transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-coenzyme A transporter 1
    Names
    AT-1
    acetyl-CoA transporter 1
    solute carrier family 33 member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001272035.1 → NP_001258964.1  acetyl-coenzyme A transporter 1 isoform 1

      See identical proteins and their annotated locations for NP_001258964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC116732, AW519598
      Consensus CDS
      CCDS17382.1
      UniProtKB/Swiss-Prot
      Q99J27, Q9WTN1
      Related
      ENSMUSP00000125713.2, ENSMUST00000160883.2
      Conserved Domains (1) summary
      TIGR00901
      Location:86 → 459
      2A0125; AmpG-like permease

    2. NM_001331067.1 → NP_001317996.1  acetyl-coenzyme A transporter 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate translation start site compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC116732

    3. NM_015728.5 → NP_056543.2  acetyl-coenzyme A transporter 1 isoform 1

      See identical proteins and their annotated locations for NP_056543.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC116732, AW519598
      Consensus CDS
      CCDS17382.1
      UniProtKB/Swiss-Prot
      Q99J27, Q9WTN1
      Related
      ENSMUSP00000029402.9, ENSMUST00000029402.15
      Conserved Domains (1) summary
      TIGR00901
      Location:86 → 459
      2A0125; AmpG-like permease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      63849744..63872154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J27.1 GenPept UniProtKB/Swiss-Prot:Q99J27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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