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    Gpx5 glutathione peroxidase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113919, updated on 17-Aug-2024

    Summary

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    Symbol
    Gpx5provided by RGD
    Full Name
    glutathione peroxidase 5provided by RGD
    Primary source
    RGD:69227
    See related
    AllianceGenome:RGD:69227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glutathione peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to act upstream of or within cellular response to oxidative stress. Predicted to be located in extracellular space and sperm plasma membrane. Orthologous to human GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 13.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (48131853..48138801)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (43436126..43443074)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (45508657..45518686)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 6 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene transfer RNA arginine (anticodon UCG) 5 Neighboring gene transfer RNA threonine (anticodon UGU) 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation. Taylor A, et al. Hum Reprod, 2013 Sep. PMID 23696541
    2. Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5. Maremanda KP, et al. Biol Trace Elem Res, 2016 Oct. PMID 27025721
    3. Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. Chabory E, et al. J Clin Invest, 2009 Jul. PMID 19546506, Free PMC Article
    4. GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations. Rejraji H, et al. Mol Reprod Dev, 2002 Sep. PMID 12211066
    5. Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase. Vernet P, et al. Mol Reprod Dev, 1997 May. PMID 9110319

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
      Title: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
    2. Diabetic testes showed decreased Nrf2, HO-1, SOD1, PCNA, and Bcl-2 expressions whereas increased COX-2, NF-kappaB, MT, IL-6, and p-ERK levels. SOD1 and GPX5 were decreased in the epididymis of diabetic rat, whereas Zn supplementation attenuated these changes.
      Title: Role of Zinc Supplementation in Testicular and Epididymal Damages in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5.
    3. Data (from studies with recombinant GPX5) suggest that GPX5 is secreted by epididymis via exocytosis/epididymosomes; then GPX5 is able to associate with (or transfer to) plasma membrane of sperm where it may protect sperm against oxidative damage.
      Title: Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epididymal secretory glutathione peroxidase
    Names
    EGLP
    GPx-5
    GSHPx-5
    epididymis-specific glutathione peroxidase-like protein
    NP_001099208.1
    XP_038951212.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105738.2 → NP_001099208.1  epididymal secretory glutathione peroxidase precursor

      See identical proteins and their annotated locations for NP_001099208.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      P30710
      UniProtKB/TrEMBL
      A0A0G2JU80, A6KN68
      Conserved Domains (1) summary
      cd00340
      Location:39 → 211
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      48131853..48138801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095284.1 → XP_038951212.1  epididymal secretory glutathione peroxidase isoform X1

      Conserved Domains (1) summary
      cl00388
      Location:40 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30710.1 GenPept UniProtKB/Swiss-Prot:P30710

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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